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Comment
. 2021 Oct 19;2(10):100430.
doi: 10.1016/j.xcrm.2021.100430.

Spiking immunotherapy with a bacterial cocktail brings T cells back to the fight

K Leigh Greathouse  1   2 , Ankan Choudhury  2
Affiliations
Comment

Spiking immunotherapy with a bacterial cocktail brings T cells back to the fight

K Leigh Greathouse et al. Cell Rep Med. .

Abstract

A recent study by Montalban-Arques et al.1 in Cell Host & Microbe shows that augmenting the function of the gut microbiota reduces tumor burden. Four Clostridiales species blocked tumor growth as efficient as chemotherapy or immunotherapy in colorectal cancer and melanoma.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
Clostridiales species (CC4) mitigate tumorigenesis and enhance immunotherapy Using microbial sequencing and pathway analysis, Montalban-Arques et al. identify a butyrate pathway that correlates with differences in tumor burden in CRC. A Clostridiales mixture (CC4) as oral gavage reduces tumor size and formation in multiple models of cancer, independent of butyrate production, and is as effective or synergistic with immunotherapy (anti-PD-1). Key in restoring tumor immunogenicity with CC4 is recruiting CD8+ T cells back to the fight. Created with BioRender.com.
See this image and copyright information in PMC

Comment on

  • Commensal Clostridiales strains mediate effective anti-cancer immune response against solid tumors.
    Montalban-Arques A, Katkeviciute E, Busenhart P, Bircher A, Wirbel J, Zeller G, Morsy Y, Borsig L, Glaus Garzon JF, Müller A, Arnold IC, Artola-Boran M, Krauthammer M, Sintsova A, Zamboni N, Leventhal GE, Berchtold L, de Wouters T, Rogler G, Baebler K, Schwarzfischer M, Hering L, Olivares-Rivas I, Atrott K, Gottier C, Lang S, Boyman O, Fritsch R, Manz MG, Spalinger MR, Scharl M. Montalban-Arques A, et al. Cell Host Microbe. 2021 Oct 13;29(10):1573-1588.e7. doi: 10.1016/j.chom.2021.08.001. Epub 2021 Aug 27. Cell Host Microbe. 2021. PMID: 34453895

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