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Comment
. 2021 Oct 19;2(10):100433.
doi: 10.1016/j.xcrm.2021.100433.

Message in a platelet: decoding platelet transcriptomes in myeloproliferative neoplasms

Susan Shapiro  1   2 , Lauren Murphy  2 , Bethan Psaila  1   2
Affiliations
Comment

Message in a platelet: decoding platelet transcriptomes in myeloproliferative neoplasms

Susan Shapiro et al. Cell Rep Med. .

Abstract

Platelets are anucleate but contain a rich repertoire of mRNAs. In this issue of Cell Reports Medicine, Shen and colleagues1 present platelet transcriptomes from patients with myeloproliferative neoplasms to study disease mechanisms and generate a predictive algorithm for fibrotic progression.

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Conflict of interest statement

S.S., L.M., and B.P. indicate no relevant conflicts of interest.

Figures

Figure 1
Figure 1
Factors influencing the platelet transcriptome Platelets are produced from megakaryocytes in the bone marrow. During thrombopoiesis, megakaryocytes package mRNAs into developing platelets. (1) The platelet transcriptome reflects the transcriptional state of the parent megakaryocytes. In myeloproliferative neoplasms (MPNs), platelets derived from the MPN clone (green) may harbor a unique transcriptional signature. The platelet transcriptome is also modified during peripheral circulation due to (2) external signals inducing specific splicing of the platelet pre-mRNA) and (3) platelet uptake of mRNAs transferred other cells. Figure created with BioRender.com (2021).
See this image and copyright information in PMC

Comment on

References

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