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. 2021 Nov;17(9):556-557.
doi: 10.1016/j.reumae.2020.03.005.

Why choose cyclosporin A as first-line therapy in COVID-19 pneumonia

Olga Sanchez-Pernaute  1 , Fredeswinda I Romero-Bueno  2 , Albert Selva-O'Callaghan  3
Affiliations

Why choose cyclosporin A as first-line therapy in COVID-19 pneumonia

Olga Sanchez-Pernaute et al. Reumatol Clin (Engl Ed). 2021 Nov.
No abstract available

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Figures

Fig. 1
Fig. 1
The graphic represents a pathogenic model of 2019-nCoV considering different virus-host cell interactions. The virus entry, replication, assembly and shedding indicating infectivity are shown at the left, while the right side displays the innate antiviral response characterized by an interferon signature. The center of the figure represents intracellular events unchained by the presence of the virus, driving cell and mitochondrial stress and eventually ending in hypoxic damage. The sites of action of different immunomodulatory drugs are marked. ACE2: angiotensin converting enzyme 2, ANT: adenine nucleotide translocation, CARD: caspase activation and recruitment domains, CQ: chloroquine, CyD: cyclophilin D, ER: endoplasmic reticulum, FK506: tacrolimus, HSR: heat shock response (also unfolded-protein response of the cytosol), IFN: interferon, IRF: interferon regulatory factor, iJAK: inhibitor of Janus kinases, MAS: macrophage activation syndrome, MAVS: mitochondrial antiviral proteins, MDA5: melanoma differentiation-activated protein 5, mtUPR: mitochondrial unfolded-protein response, NFκB: transcriptional activator kappa B, polyA: polyadenylated, PTM: postranslational modifications, RIG-1: retinoic acid inducible gene 1, RLR: RIG-1-like receptors, Th: T helper lymphocytes, TCZ: tocilizumab, vRNA: viral RNA.
See this image and copyright information in PMC

Dataset described in

  • COVID-19: consider cytokine storm syndromes and immunosuppression.
    Mehta P, McAuley DF, Brown M, Sanchez E, Tattersall RS, Manson JJ; HLH Across Speciality Collaboration, UK. Mehta P, et al. Lancet. 2020 Mar 28;395(10229):1033-1034. doi: 10.1016/S0140-6736(20)30628-0. Epub 2020 Mar 16. Lancet. 2020. PMID: 32192578 Free PMC article. No abstract available.

References

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