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Review
. 2022 Nov-Dec;88 Suppl 4(Suppl 4):S205-S211.
doi: 10.1016/j.bjorl.2021.07.013. Epub 2021 Oct 17.

Primary oral leiomyosarcoma of the maxillary bone and sinus: case report and up-to-date review of literature

Niccolò Lombardi  1 , Elena M Varoni  2 , Dimitri Rabbiosi  3 , Marco Cucurullo  3 , Laura Moneghini  4 , Giovanni Lodi  2
Affiliations
Review

Primary oral leiomyosarcoma of the maxillary bone and sinus: case report and up-to-date review of literature

Niccolò Lombardi et al. Braz J Otorhinolaryngol. 2022 Nov-Dec.
No abstract available

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Figures

Figure 1
Figure 1
Clinical picture of a large growing mass of the upper maxilla extended on both buccal and palatal sides (A; B).
Figure 2
Figure 2
Wide maxillary osteolytic lesion associated with dental root resorption and involvement of the right maxillary sinus: orthopantomography (a), axial CT (b), 3D reconstruction (c) and PET (d) images.
Figure 3
Figure 3
Hematoxylin and eosin stains show, under the oral epithelium, a sarcomatous proliferation characterized by fascicles of medium/large size spindle cells with abundant eosinophilic cytoplasm and well-defined cell borders (A). The nuclei are spindle or oval with mild to marked atypia. Both typical and atypical mitotic activity is easily found together a mild lymphocytic infiltrate without necrosis. Immunochemistry shows diffuse expression of smooth muscle actin (B) and HHF35 (C), and desmin (D) at a minor degree.
Figure 4
Figure 4
Total maxillectomy and reconstruction with fibula free flap: orthopantomography (A) and 3D-CT images (B); clinical picture at follow-up examination, 6-months after surgical treatment (C).
See this image and copyright information in PMC

References

    1. Suárez-Alén F., Otero-Rey E., Peñamaría-Mallõn M., García-García A., Blanco-Carriõn A. Oral leiomyosarcoma: the importance of early diagnosis. Gerodontology. 2015;32:314–317. - PubMed
    1. Saluja T.S., Iyer J., Singh S.K. Leiomyosarcoma: prognostic outline of a rare head and neck malignancy. Oral Oncol. 2019;95:100–105. - PubMed
    1. Ko E. Primary oral leiomyosarcoma: A systematic review and update. J Oral Pathol Med. 2019;48(9):780–787. - PubMed
    1. Azevedo R.S., Pires F.R., Gouvêa A.F., Lopes M.A., Jorge J. Leiomyosarcomas of the oral cavity: Report of a radiation-associated and a metastatic case. Oral Maxillofac Surg. 2012;16:227–232. - PubMed
    1. Ko E.M., McHugh J.B. Primary leiomyosarcoma of the buccal mucosa: report of a case and review of the literature. Head Neck Pathol. 2018;12:529–533. - PMC - PubMed