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Case Reports
. 2022 Jan;21(1):e5-e7.
doi: 10.1016/j.jcf.2021.10.003. Epub 2021 Oct 29.

No drug-drug interaction between tezacaftor-ivacaftor and clofazimine: A case report

S E M Vonk  1 , S W J Terheggen-Lagro  2 , L M Mouissie  3 , R A A Mathôt  1 , E M Kemper  4 ; Amsterdam Mucociliary Clearance Disease (AMCD) research group
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Free article
Case Reports

No drug-drug interaction between tezacaftor-ivacaftor and clofazimine: A case report

S E M Vonk et al. J Cyst Fibros. 2022 Jan.
Free article

Abstract

In this case report the potential drug-drug interaction between cytochrome P450 (CYP) 3A4 substrates tezacaftor-ivacaftor and CYP3A4/5 inhibitor clofazimine is investigated in a patient with cystic fibrosis. Exposure to tezacaftor, ivacaftor and its metabolites was assessed by determination of the area under the plasma concentration versus time curve (AUC0-24 h for tezacaftor and AUC0-12 h for ivacaftor and its metabolite) before start of clofazimine and 8 and 115 days after start of clofazimine. The AUC-ratio at day 115 and pre-start was 1.09, 1.45 and 0.747 for ivacaftor, hydroxymethyl ivacaftor and tezacaftor, respectively. This case suggests that clofazimine exhibits no clinically relevant increase in exposure to tezacaftor and ivacaftor.

Keywords: Clofazimine; Drug-drug interaction; Tezacaftor-ivacaftor.

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Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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