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. 1987 Aug;84(16):5962-6.
doi: 10.1073/pnas.84.16.5962.

Molecular cloning of a brain-specific calcium/calmodulin-dependent protein kinase

C R Lin, M S Kapiloff, S Durgerian, K Tatemoto, A F Russo, P Hanson, H Schulman, M G Rosenfeld

Molecular cloning of a brain-specific calcium/calmodulin-dependent protein kinase

C R Lin et al. Proc Natl Acad Sci U S A. 1987 Aug.

Abstract

A calcium/calmodulin-dependent protein kinase type II (CaM-K) alpha-subunit cDNA has been cloned from rat brain. This enzyme is encoded by a 5.1-kilobase mRNA expressed exclusively in the brain. Hybridization histochemistry reveals that the CaM-K mRNA expression corresponds to the distribution of the immunoreactive alpha-subunit protein, suggesting that the high enzyme levels in specific brain areas reflect regional differences in gene expression. The sequence of CaM-K alpha-subunit cDNA indicates a 478-amino acid (54-kDa) protein with three functional domains. The domain organization suggests a structural model for calcium/calmodulin-dependent and independent states that might subserve short- and long-term responses to transient stimuli.

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References

    1. Proc Natl Acad Sci U S A. 1984 Feb;81(3):945-9 - PubMed
    1. Annu Rev Neurosci. 1987;10:459-76 - PubMed
    1. Nature. 1984 May 31-Jun 6;309(5967):418-25 - PubMed
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