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Clinical Trial
. 1978 May 5;200(4341):567-8.
doi: 10.1126/science.347574.

Schizophrenic symptoms improve with apomorphine

C A Tamminga, M H Schaffer, R C Smith, J M Davis
Clinical Trial

Schizophrenic symptoms improve with apomorphine

C A Tamminga et al. Science. .

Abstract

Eighteen chronic schizophrenic patients received subcutaneous doses of apomorphine, a dopamine receptor agonist, and of placebo in separate trials. A significant improvement in psychotic symptoms occurred after apomorphine compared to placebo. The results are interpreted as a consequence of presynaptic dopamine receptor activation by apomorphine with a subsequent decrease in dopamine-mediated neural transmission.

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