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Review
. 2022 Mar;22(3):e202100240.
doi: 10.1002/tcr.202100240. Epub 2021 Nov 10.

Ortho C-H Functionalization of 2-Arylimidazo[1,2-a]pyridines

Sumit Ghosh  1 , Sudip Laru  1 , Alakananda Hajra  1
Affiliations
Review

Ortho C-H Functionalization of 2-Arylimidazo[1,2-a]pyridines

Sumit Ghosh et al. Chem Rec. 2022 Mar.

Abstract

C-H activation and functionalization is quite promising in recent days as the strategy offers a go-to general method for different bond formations and hence grants synthetic versatility. At the same time, imidazopyridine, a fused bicycle of imidazole moiety with pyridine ring, has a profound impact due to its ubiquitous and prodigious application in medicinal as well as material chemistry. The presence of N-1 atom in 2-arylImidazo[1,2-a]pyridine facilitates the coordination with metal catalysts leading to the formation of ortho-substituted products. This review summarizes all the articles on ortho C-H functionalization of 2-arylImidazo[1,2-a]pyridines published till August 2021.

Keywords: C−H activation; Directed C−H functionalization; Imidazo[1,2-a]pyridines; Metal catalysis; Ortho C−H functionalization.

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