SPRINT Revisited: Updated Results and Implications

Jackson T Wright Jr¹, Paul K Whelton², Karen C Johnson³, Joni K Snyder⁴, David M Reboussin⁵, William C Cushman³, Jeff D Williamson⁶, Nicholas M Pajewski⁵, Alfred K Cheung⁷, Cora E Lewis⁸, Suzanne Oparil⁹, Michael V Rocco¹⁰, Srinivasan Beddhu⁷, Lawrence J Fine⁴, Jeffrey A Cutler⁴, Walter T Ambrosius⁵, Mahboob Rahman¹, Carolyn H Still¹¹, Zhengyi Chen¹², Curtis Tatsuoka¹²; SPRINT Research Group

Affiliations

¹ From the Division of Nephrology and Hypertension, University Hospitals Cleveland Medical Center (J.T.W., M.R.), Case Western Reserve University, Cleveland, OH.
² Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana (P.K.W.).
³ Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis (K.C.J., W.C.C.).
⁴ Clinical Applications and Prevention Branch, National Heart, Lung, and Blood Institute, Bethesda, MD (J.K.S., L.J.F., J.A.C.).
⁵ Department of Biostatistics and Data Science (D.M.R., N.M.P., W.T.A.) Wake Forest School of Medicine, Winston-Salem, NC.
⁶ Section of Gerontology and Geriatric Medicine (J.D.W.), Wake Forest School of Medicine, Winston-Salem, NC.
⁷ Renal Section, Veterans Affairs Salt Lake City Healthcare System, Utah (A.K.C., S.B.).
⁸ Division of Nephrology and Hypertension, University of Utah, Salt Lake City (A.K.C., S.B.).
⁹ Department of Epidemiology (C.E.L.), University of Alabama at Birmingham.
¹⁰ Section on Nephrology (M.V.R.), Wake Forest School of Medicine, Winston-Salem, NC.
¹¹ Frances Payne Bolton School of Nursing (C.H.S.), Case Western Reserve University, Cleveland, OH.
¹² Department of Medicine (S.O.), University of Alabama at Birmingham.

PMID: 34757768
PMCID: PMC8824314
DOI: 10.1161/HYPERTENSIONAHA.121.17682

Review

SPRINT Revisited: Updated Results and Implications

Jackson T Wright Jr et al. Hypertension. 2021 Dec.

. 2021 Dec;78(6):1701-1710.

doi: 10.1161/HYPERTENSIONAHA.121.17682. Epub 2021 Nov 10.

Authors

Affiliations

¹ From the Division of Nephrology and Hypertension, University Hospitals Cleveland Medical Center (J.T.W., M.R.), Case Western Reserve University, Cleveland, OH.
² Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana (P.K.W.).
³ Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis (K.C.J., W.C.C.).
⁴ Clinical Applications and Prevention Branch, National Heart, Lung, and Blood Institute, Bethesda, MD (J.K.S., L.J.F., J.A.C.).
⁵ Department of Biostatistics and Data Science (D.M.R., N.M.P., W.T.A.) Wake Forest School of Medicine, Winston-Salem, NC.
⁶ Section of Gerontology and Geriatric Medicine (J.D.W.), Wake Forest School of Medicine, Winston-Salem, NC.
⁷ Renal Section, Veterans Affairs Salt Lake City Healthcare System, Utah (A.K.C., S.B.).
⁸ Division of Nephrology and Hypertension, University of Utah, Salt Lake City (A.K.C., S.B.).
⁹ Department of Epidemiology (C.E.L.), University of Alabama at Birmingham.
¹⁰ Section on Nephrology (M.V.R.), Wake Forest School of Medicine, Winston-Salem, NC.
¹¹ Frances Payne Bolton School of Nursing (C.H.S.), Case Western Reserve University, Cleveland, OH.
¹² Department of Medicine (S.O.), University of Alabama at Birmingham.

PMID: 34757768
PMCID: PMC8824314
DOI: 10.1161/HYPERTENSIONAHA.121.17682

Abstract

The SPRINT (Systolic Blood Pressure Intervention Trial) results have influenced clinical practice but have also generated discussion regarding the validity, generalizability, and importance of the findings. Following the SPRINT primary results manuscript in 2015, additional results and analyses of the data have addressed these concerns. The primary objective of this article is to respond to key questions that have been raised.

Keywords: blood pressure; cardiovascular disease; controlled clinical trial; heart failure; hypertension; myocardial infarction.

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Figures

**Figure 1.**
Primary outcome in prespecified (age, sex, race, and history of cardiovascular disease [CVD] and CKD) and post hoc (Hispanic ethnicity, frailty, metabolic syndrome, and prediabetes) subgroups.^,,,,,

**Figure 2.**
All-cause mortality outcome in prespecified (age, sex, race, and history of cardiovascular disease [CVD] and CKD) and post hoc (Hispanic ethnicity, frailty, metabolic syndrome, and prediabetes) subgroups. ^,,,,,

See this image and copyright information in PMC

References

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1. Kjeldsen SE, Lund-Johansen P, Nilsson PM and Mancia G. Unattended Blood Pressure Measurements in the Systolic Blood Pressure Intervention Trial: Implications for Entry and Achieved Blood Pressure Values Compared With Other Trials. Hypertension 2016;67:808–12. - PubMed

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SPRINT Revisited: Updated Results and Implications

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SPRINT Revisited: Updated Results and Implications

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