Candida-induced asthma steps up to the plate-lets

Katherine Lagree¹, David M Underhill²

Affiliations

¹ Research Division of Immunology, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA; F. Widjaja Foundation Inflammatory Bowel & Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA; The Karsh Division of Gastroenterology and Hepatology, Department of Medicine Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
² Research Division of Immunology, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA; F. Widjaja Foundation Inflammatory Bowel & Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA; The Karsh Division of Gastroenterology and Hepatology, Department of Medicine Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA. Electronic address: david.underhill@csmc.edu.

PMID: 34758334
DOI: 10.1016/j.immuni.2021.10.014

Comment

Candida-induced asthma steps up to the plate-lets

Katherine Lagree et al. Immunity. 2021.

. 2021 Nov 9;54(11):2442-2444.

doi: 10.1016/j.immuni.2021.10.014.

Authors

Katherine Lagree¹, David M Underhill²

Affiliations

¹ Research Division of Immunology, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA; F. Widjaja Foundation Inflammatory Bowel & Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA; The Karsh Division of Gastroenterology and Hepatology, Department of Medicine Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
² Research Division of Immunology, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA; F. Widjaja Foundation Inflammatory Bowel & Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA; The Karsh Division of Gastroenterology and Hepatology, Department of Medicine Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA. Electronic address: david.underhill@csmc.edu.

PMID: 34758334
DOI: 10.1016/j.immuni.2021.10.014

Abstract

Fungal proteases are well-known allergens. In this issue of Immunity, Wu et al. (2021) observe that allergic airway responses to Candida albicans are mediated by the peptide toxin candidalysin rather than proteases. Candidalysin promotes these responses by stimulating platelets to release the Wnt antagonist Dickkopf-1.

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Candida albicans elicits protective allergic responses via platelet mediated T helper 2 and T helper 17 cell polarization.
Wu Y, Zeng Z, Guo Y, Song L, Weatherhead JE, Huang X, Zeng Y, Bimler L, Chang CY, Knight JM, Valladolid C, Sun H, Cruz MA, Hube B, Naglik JR, Luong AU, Kheradmand F, Corry DB. Wu Y, et al. Immunity. 2021 Nov 9;54(11):2595-2610.e7. doi: 10.1016/j.immuni.2021.08.009. Epub 2021 Sep 9. Immunity. 2021. PMID: 34506733 Free PMC article.

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Candida-induced asthma steps up to the plate-lets

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Candida-induced asthma steps up to the plate-lets

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