Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2021 Oct 15;14(10):1065-1068.
eCollection 2021.

Huge solitary necrotic nodule of the liver: a rare case report with review of literature

Xinyue Zhang  1 , Weilan Fang  1 , Liangtao Zeng  1 , Fanrong Liu  1
Affiliations
Case Reports

Huge solitary necrotic nodule of the liver: a rare case report with review of literature

Xinyue Zhang et al. Int J Clin Exp Pathol. .

Abstract

Solitary necrotic nodule of the liver (SNNL) is an uncommon disease in clinical practice, and its pathogenesis is still unclear. Here, we report the case of a 35-year-old woman. After physical examination, the patient was found to have a liver neoplasm, and there were no other physical complaints. Abdominal contrast-enhanced computed tomography (CT) showed the presence of a hypodense lesion. The patient opted for surgery to eliminate the lesion. Pathologic examination revealed an isolated necrotic nodular lesion with a size of 12 cm×10 cm×10 cm. The patient had a history of hepatitis B infection. To our knowledge, this is the largest SNNL ever reported and the first case with a history of hepatitis B infection.

Keywords: Liver tumor; pathology; solitary necrotic nodule.

PubMed Disclaimer

Conflict of interest statement

None.

Figures

Figure 1
Figure 1
Multinucleated giant cells appeared at the edge of the necrotic area. (Hematoxylin and eosin staining, magnification ×100).
Figure 2
Figure 2
There were several cavities in the necrotic area, and the surrounding cavities showed cystic mural structures. (Hematoxylin and eosin staining, magnification ×100).
See this image and copyright information in PMC

References

    1. Colagrande S, Politi LS, Messerini L, Mascalchi M, Villari N. Solitary necrotic nodule of the liver: imaging and correlation with pathologic features. Abdom Imaging. 2003;28:41–44. - PubMed
    1. Patti R, Cabibi D, Sparacello M, Di Vita G, Montalto G. Solitary necrotic nodule of the liver: different pathological findings express a different histogenesis. Case Rep Gastroenterol. 2008;2:149–154. - PMC - PubMed
    1. Wang LX, Liu K, Lin GW, Zhai RY. Solitary necrotic nodules of the liver: histology and diagnosis with CT and MRI. Hepat Mon. 2012;12:e6212. - PMC - PubMed
    1. Colagrande S, Paolucci ML, Messerini L, Schima W, Stadler A, Bartolotta TV, Vanzulli A, Brancatelli G. Solitary necrotic nodules of the liver: cross-sectional imaging findings and follow-up in nine patients. AJR Am J Roentgenol. 2008;191:1122–1128. - PubMed
    1. Hwang JY, Lee JE, Jung MJ. A challenging case of solitary necrotic nodules of the liver mimicking hepatic metastases: CT, MRI, and PET-CT findings. J Belg Soc Radiol. 2020;104:16. - PMC - PubMed

Publication types

LinkOut - more resources