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. 2021 Nov 1:2021:9024919.
doi: 10.1155/2021/9024919. eCollection 2021.

Observation on the Efficacy of Shouhui Tongbian Capsule in the Treatment of Functional Constipation and Study on Its Regulatory Effect on Intestinal Flora

Hongxi Zhang  1 , Bao Han  2 , Zhiyun Zhang  3 , Zhenguo Tian  1 , Yongduo Yu  1
Affiliations

Observation on the Efficacy of Shouhui Tongbian Capsule in the Treatment of Functional Constipation and Study on Its Regulatory Effect on Intestinal Flora

Hongxi Zhang et al. J Healthc Eng. .

Retraction in

Abstract

Functional constipation is relatively common in both adults and children, exhibiting similar symptoms. However, there are significant differences in the epidemiology, symptomatology, pathophysiology, diagnostic tests, and treatment management of functional constipation by age. The treatment of functional constipation is generally based on lifestyle interventions, pelvic floor interventions, and pharmacotherapy. Pharmacological treatment is popular as the most direct and effective modality, especially the herbal preparations (e.g., Shouhui Tongbian capsule), which are popular for their lower toxic side effects and less physiological reactions. In our clinical study, patients with functional constipation who took Shouhui Tongbian capsules for a longer period of time showed significantly better improvement than those who took them for a shorter period of time (P < 0.001). Relative to the duration of the disease, the improvement effect was higher in patients with short duration of the disease than in patients with long duration of the disease (P < 0.001). What's more, Shouhui Tongbian capsule had a regulating effect on intestinal flora, and the regulating effect was stronger in patients with a shorter disease duration.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
The mechanism diagram of the Shouhui Tongbian capsule on functional constipation.
Figure 2
Figure 2
Demographic characteristics of subjects.
Figure 3
Figure 3
Effect of Shouhui Tongbian capsule on Wexner's constipation score in patients with different courses (∗P < 0.001). (a) Wexner constipation score of patients. (b) Evaluation of the curative effect of Shouhui Tongbian capsule on patients with different courses.
Figure 4
Figure 4
The effect of Shouhui Tongbian capsule on the treatment effect of TCM symptoms in patients with different courses of treatment (∗P < 0.001). (a) TCM symptom therapeutic effect score in patients. (b) Evaluation of the treatment effect of the Shouhui Tongbian capsule in traditional Chinese medicine.
Figure 5
Figure 5
Patient quality of life score.
Figure 6
Figure 6
Patient satisfaction evaluation.
Figure 7
Figure 7
Patient safety evaluation. (a) Patient safety rating evaluation. (b) The occurrence of adverse reactions in patients.
Figure 8
Figure 8
The regulating effect of the Shouhui Tongbian capsule on the intestinal flora of patients with different courses. (a) 0–6 months. (b) 6–12 months. (c) 1–5 years. (d) >5 years.
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