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. 2021 Jul-Sep;11(3):117-122.
doi: 10.4103/IJCIIS.IJCIIS_98_20. Epub 2021 Sep 25.

Validation of the vasoactive-inotropic score in predicting pediatric septic shock mortality: A retrospective cohort study

Antonius Hocky Pudjiadi  1 , Dwi Lestari Pramesti  1 , Sudung O Pardede  1 , Mulyadi M Djer  1 , Rinawati Rohsiswatmo  1 , Nastiti Kaswandani  1
Affiliations

Validation of the vasoactive-inotropic score in predicting pediatric septic shock mortality: A retrospective cohort study

Antonius Hocky Pudjiadi et al. Int J Crit Illn Inj Sci. 2021 Jul-Sep.

Abstract

Introduction: Mortality in pediatric septic shock remains very high. Vasoactive-inotropic score (VIS) is widely used to predict prognosis in patients with heart disease. It is a simple method that was initially used as a predictor of morbidity and mortality in postoperative patients with congenital heart diseases. Previous reports showed that high VIS score was associated with high mortality in pediatric sepsis. However, its discriminative value remains unclear. We aim to explore the discriminative value of VIS in predicting mortality in pediatric septic shock patients.

Methods: We conducted a retrospective cohort study on medical records of septic shock patients who received care in the pediatric intensive care unit (PICU). We screened medical records of pediatric patients which were diagnosed with septic shock and admitted to the PICU and received vasoactive/inotropic score for more than 8 h. Other supporting examination results were recorded, such as organ function evaluation for calculation of Pediatric Logistic Organ Dysfunction-2 (PELOD-2) score. The outcome of patients was recorded. The receiver operating curve was constructed to calculate the area under the curve (AUC), sensitivity, and specificity of each cutoff point.

Results: We obtained the optimum cutoff point of VIS > 11 with 78.87% sensitivity and 72.22% specificity. AUC positive was 0.779 (P < 0.001); predictive value and negative predictive value were 91.80% and 46.43%, respectively.

Conclusion: VIS > 11 has a good ability to predict mortality in children with septic shock.

Keywords: Mortality; pediatrics; sepsis; vasoactive-inotropic score.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Receiver operating curve of vasoactive inotropic score,Pediatric Logistic Organ Dysfunction-2 score without lactate in predicting mortality in pediatric septic shock
See this image and copyright information in PMC

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