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. 2021 Oct 25:11:674277.
doi: 10.3389/fcimb.2021.674277. eCollection 2021.

Clinical Predictors of COVID-19 Severity and Mortality: A Perspective

Jitender Sharma  1 , Roopali Rajput  2 , Manika Bhatia  3 , Pooja Arora  3 , Vikas Sood  2
Affiliations

Clinical Predictors of COVID-19 Severity and Mortality: A Perspective

Jitender Sharma et al. Front Cell Infect Microbiol. .

Abstract

The COVID-19 pandemic has caused huge socio-economic losses and continues to threat humans worldwide. With more than 4.5 million deaths and more than 221 million confirmed COVID-19 cases, the impact on physical, mental, social and economic resources is immeasurable. During any novel disease outbreak, one of the primary requirements for effective mitigation is the knowledge of clinical manifestations of the disease. However, in absence of any unique identifying characteristics, diagnosis/prognosis becomes difficult. It intensifies misperception and leads to delay in containment of disease spread. Numerous clinical research studies, systematic reviews and meta-analyses have generated considerable data on the same. However, identification of some of the distinct clinical signs and symptoms, disease progression biomarkers and the risk factors leading to adverse COVID-19 outcomes warrant in-depth understanding. In view of this, we assessed 20 systematic reviews and meta-analyses with an intent to understand some of the potential independent predictors/biomarkers/risk factors of COVID-19 severity and mortality.

Keywords: SARS-CoV-2; biomarkers; diabetes; obesity; prognosis; radiological; risk factors; sleep.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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