Review

. 2022 Mar;233(5):2047-2057.

doi: 10.1111/nph.17853. Epub 2021 Nov 29.

MicroRNA482/2118, a miRNA superfamily essential for both disease resistance and plant development

Yanqing Zhang^{1

2

3

4}, Muhammad Waseem^{1

2

3

4}, Zaohai Zeng^{1

2

3

4}, Jing Xu⁴, Chengjie Chen^{1

2

3

4}, Yuanlong Liu^{1

2

3

4}, Jixian Zhai^{5

6}, Rui Xia^{1

2

3

4}

Affiliations

¹ State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, South China Agricultural University, Guangzhou, Guangdong, 510640, China.
² Guangdong Laboratory for Lingnan Modern Agriculture, South China Agricultural University, Guangzhou, Guangdong, 510640, China.
³ Key Laboratory of Biology and Germplasm Enhancement of Horticultural Crops in South China, Ministry of Agriculture and Rural Affairs, South China Agricultural University, Guangzhou, Guangdong, 510640, China.
⁴ Guangdong Litchi Engineering Research Center, College of Horticulture, South China Agricultural University, Guangzhou, Guangdong, 510640, China.
⁵ Department of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, 518055, China.
⁶ Institute of Plant and Food Science, Southern University of Science and Technology, Shenzhen, 518055, China.

PMID: 34761409
DOI: 10.1111/nph.17853

Free article

Review

MicroRNA482/2118, a miRNA superfamily essential for both disease resistance and plant development

Yanqing Zhang et al. New Phytol. 2022 Mar.

Free article

. 2022 Mar;233(5):2047-2057.

doi: 10.1111/nph.17853. Epub 2021 Nov 29.

Authors

Yanqing Zhang^{1

2

3

4}, Muhammad Waseem^{1

2

3

4}, Zaohai Zeng^{1

2

3

4}, Jing Xu⁴, Chengjie Chen^{1

2

3

4}, Yuanlong Liu^{1

2

3

4}, Jixian Zhai^{5

6}, Rui Xia^{1

2

3

4}

Affiliations

¹ State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, South China Agricultural University, Guangzhou, Guangdong, 510640, China.
² Guangdong Laboratory for Lingnan Modern Agriculture, South China Agricultural University, Guangzhou, Guangdong, 510640, China.
³ Key Laboratory of Biology and Germplasm Enhancement of Horticultural Crops in South China, Ministry of Agriculture and Rural Affairs, South China Agricultural University, Guangzhou, Guangdong, 510640, China.
⁴ Guangdong Litchi Engineering Research Center, College of Horticulture, South China Agricultural University, Guangzhou, Guangdong, 510640, China.
⁵ Department of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, 518055, China.
⁶ Institute of Plant and Food Science, Southern University of Science and Technology, Shenzhen, 518055, China.

PMID: 34761409
DOI: 10.1111/nph.17853

Abstract

MicroRNAs (miRNAs) are a class of 21-24 nucleotides (nt) noncoding small RNAs ubiquitously distributed across the plant kingdom. miR482/2118, one of the conserved miRNA superfamilies originating from gymnosperms, has divergent main functions in core-angiosperms. It mainly regulates NUCLEOTIDE BINDING SITE-LEUCINE-RICH REPEAT (NBS-LRR) genes in eudicots, functioning as an essential component in plant disease resistance; in contrast, it predominantly targets numerous long noncoding RNAs (lncRNAs) in monocot grasses, which are vital for plant reproduction. Usually, miR482/2118 is 22-nt in length, which can trigger the production of phased small interfering RNAs (phasiRNAs) after directed cleavage. PhasiRNAs instigated from target genes of miR482/2118 enhance their roles in corresponding biological processes by cis-regulation on cognate genes and expands their function to other pathways via trans activity on different genes. This review summarizes the origin, biogenesis, conservation, and evolutionary characteristics of the miR482/2118 superfamily and delineates its diverse functions in disease resistance, plant development, stress responses, etc.

Keywords: NBS-LRR; disease resistance; evolution; function divergence; genic male sterility; miR482/2118 superfamily; phasiRNAs; reproduction.

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MicroRNA482/2118, a miRNA superfamily essential for both disease resistance and plant development

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MicroRNA482/2118, a miRNA superfamily essential for both disease resistance and plant development

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