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Observational Study
. 2022 Jan;42(1):48-58.
doi: 10.1111/opo.12918. Epub 2021 Nov 10.

An evaluation of the IOLMaster 700 and its agreement with the IOLMaster v3 in children

Rebecca E Leighton  1 , Karen Mm Breslin  1 , Kathryn J Saunders  1 , Sara J McCullough  1
Affiliations
Observational Study

An evaluation of the IOLMaster 700 and its agreement with the IOLMaster v3 in children

Rebecca E Leighton et al. Ophthalmic Physiol Opt. 2022 Jan.

Abstract

Purpose: To evaluate the repeatability and reproducibility of the swept-source optical coherence tomographer Zeiss IOLMaster 700 and compare its outputs with those obtained using partial coherence interferometry (Zeiss IOLMaster v3) in a healthy, paediatric population.

Methods: This is a cross-sectional, observational study. Examiner 1 took two sets of biometric measurements (axial length [AL], mean corneal radius of curvature [Kmean ], anterior chamber depth [ACD] and lens thickness [LT]) using the IOLMaster 700, and one set of measurements (AL, Kmean and ACD) using the IOLMaster v3. Examiner 2 took one full set of measurements using the IOLMaster 700. Mean differences and 95% limits of agreement (LOA) were calculated, and Bland and Altman plots used to explore repeatability and reproducibility of the IOLMaster 700 alongside establishing its agreement with the IOLMaster v3.

Results: Mean participant age was 7.52 ± 0.58 years. Repeatability analyses demonstrated small mean differences and narrow 95% LOA for AL (0.001, -0.013 to 0.015 mm), Kmean (0.002, -0.020 to 0.024 mm), ACD (-0.003, -0.031 to 0.024 mm) and LT (0.001, -0.024 to 0.026 mm), respectively. Similarly, small mean differences and narrow 95% LOA established excellent reproducibility (AL 0.001, -0.016 to 0.018 mm; Kmean -0.001, -0.027 to 0.025 mm; ACD -0.010, -0.041 to 0.021 mm; LT 0.002, -0.016 to 0.020 mm). The IOLMaster 700 and IOLMaster v3 demonstrated good agreement with small mean differences and narrow 95% LOA (AL 0.009, -0.034 to 0.052 mm; Kmean 0.016, -0.013 to 0.044 mm; ACD 0.134, 0.055 to 0.212 mm).

Conclusions: When used within a paediatric population, these data demonstrate the IOLMaster 700 to be highly repeatable and reproducible for measures of AL, Kmean , ACD and LT. There is excellent inter-instrument agreement between the IOLMaster 700 and IOLMaster v3 for measures of AL and Kmean . ACD measurements show weaker agreement. These data will be useful when considering reports from population-based studies of refractive error and clinical myopia research.

Keywords: IOLMaster; agreement; axial length; myopia; repeatability; reproducibility.

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