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Review
. 2021 Nov 1;49(6):56-59.
doi: 10.15586/aei.v49i6.474. eCollection 2021.

Practical protocol of the food allergy committee of the seicap on open oral food challenges to nuts

Cristina Blasco Valero  1 , Ángela Claver Monzón  2 , Natalia Molini Menchón  3 , Antonio Martorell  4 , L Aragonés  5 , Carlos García Magán  6   5 , Sara Pereiro Fernández  6 , Celia Pinto Fernández  7 , Mónica Piquer Gibert  8 , Ana Prieto Del Prado  9 , Laura Valdesoiro Navarrete  10 , Marta Vázquez Ortiz  11 , Luis Echeverría Zudaire  12
Affiliations
Review

Practical protocol of the food allergy committee of the seicap on open oral food challenges to nuts

Cristina Blasco Valero et al. Allergol Immunopathol (Madr). .

Abstract

Food allergy is rising rapidly among children, and allergy to nuts is one of the most prevalent allergies among them. The category "nuts and seeds" include several plant foods from different botanical families, very different from each other. It is not uncommon to detect co-sensitization to different nuts. However, true co-allergy is less frequent. Up to 80% of patients with positive skin prick tests or specific IgE without true history of reaction who avoid certain nuts, might tolerate them in an Oral Food Challenge (OFC). Although molecular diagnostic techniques help to improve nut allergy diagnosis, OFC still remains the gold standard. For this reason, after reviewing the current bibliography and the recommendations of different allergy societies on standardization of open OFC, the Food Allergy Committee of the Spanish Society of Pediatric Allergy, Asthma and Clinical Immunology (SEICAP) food allergy working group proposed a unified protocol to undertake these OFC, which include preliminary recommendations, unification of total dose, number of doses and interval between doses. Additionally, this group offers an interactive table to facilitate calculation of doses specific to each nut under study.

Keywords: food allergy; nuts; oral food challenge; seeds.

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References

    1. 1. Peters RL, Koplin JJ, Gurrin LC, Dharmage SC, Wake M, Ponsonby AL, et al. The prevalence of food allergy and other allergic diseases in early childhood in a population-based study: HealthNuts age 4-year follow-up. J Allergy Clin Immunol. 2017 Jul;140(1):145–153. 10.1016/j.jaci.2017.02.019 - DOI
    1. 2. Midun E, Radulovic S, Brough H, Caubet JC. Recent advances in the management of nut allergy. World Allergy Organ J. 2021 Jan 13;14(1):100491. 10.1016/j.waojou.2020.100491 - DOI
    1. 3. Eigenmann PA, Lack G, Mazon A, Nieto A, Haddad D, Brough HA, et al. Managing nut allergy: a remaining clinical challenge. J Allergy Clin Immunol Pract. 2017 Mar–Apr;5(2):296–300. 10.1016/j.jaip.2016.08.014 - DOI
    1. 4. Gur CP, Buyuktiryaki B, Soyer O, Murat SU, Sack-esen C, Sekerel BE. Phenotypical characterization of tree nutsand peanut allergies in east mediterranean children. Allergol Immunopathol (Madr). 2020 Jul-Aug;48(4):316–322. 10.1016/j.aller.2019.07.005 - DOI
    1. 5. Datema MR, Zuidmeer-Jongejan L, Asero R, Barreales L, Belohlavkova S, de Blay F, et al. Hazelnut allergy across europedissected molecularly: A EuroPrevall outpatient clinic survey. JAllergy Clin Immunol. 2015;136:382–391. 10.1016/j.jaci.2014.12.1949 - DOI

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