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Comment
. 2021 Nov 11;6(1):394.
doi: 10.1038/s41392-021-00814-x.

A pan-cancer fingerprint: common molecular denominators of the human tumor microenvironment

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Comment

A pan-cancer fingerprint: common molecular denominators of the human tumor microenvironment

Susanna S Ng et al. Signal Transduct Target Ther. .
No abstract available

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Four distinct pan-cancer tumor microenvironment (TME) subtypes. The schematic summarizes the features of the TME that define the immune-enriched, fibrotic (IE/F), immune-enriched, non-fibrotic (IE), fibrotic (F), and desert/immune-depleted (D) subtypes. These subtypes can predict immunotherapy response and survival outcome. The integration of subtype-defining gene expression signatures with data of genomic alterations generates a global visualization of tumors, termed the Molecular Functional (MF) portrait. TMB, tumor mutational burden. Figure generated on Biorender.com

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References

    1. Bagaev A, et al. Conserved pan-cancer microenvironment subtypes predict response to immunotherapy. Cancer Cell. 2021;39:845–865.e7. doi: 10.1016/j.ccell.2021.04.014. - DOI - PubMed
    1. Donoghue MTA, Schram AM, Hyman DM, Taylor BS. Discovery through clinical sequencing in oncology. Nat. Cancer. 2020;1:774–783. doi: 10.1038/s43018-020-0100-0. - DOI - PMC - PubMed
    1. Kubli, S. P., Berger, T., Araujo, D. V., Siu, L. L. & Mak, T. W. Beyond immune checkpoint blockade: emerging immunological strategies. Nat. Rev. Drug Discov. 1–21, 10.1038/s41573-021-00155-y (2021). - PubMed
    1. Charoentong P, et al. Pan-cancer immunogenomic analyses reveal genotype-immunophenotype relationships and predictors of response to checkpoint blockade. Cell Rep. 2017;18:248–262. doi: 10.1016/j.celrep.2016.12.019. - DOI - PubMed
    1. Thorsson V, et al. The immune landscape of cancer. Immunity. 2018;48:812–830.e14. doi: 10.1016/j.immuni.2018.03.023. - DOI - PMC - PubMed

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