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Case Reports
. 2021 Nov 7;13(11):e19335.
doi: 10.7759/cureus.19335. eCollection 2021 Nov.

Ruxolitinib-Associated Phaeohyphomycosis: A Case Report

Rory Marples  1 , Milton Micallef  2 , Claudia Whyte  2
Affiliations
Case Reports

Ruxolitinib-Associated Phaeohyphomycosis: A Case Report

Rory Marples et al. Cureus. .

Abstract

We present the findings of a rare fungal infection phaeohyphomycosis caused by Pleurostoma richardsiae (P. richardsiae) in an immunocompromised 82-year-old male with myelodysplastic syndrome on treatment with the Janus kinase inhibitor ruxolitinib. Hematologists, infectious disease physicians, and surgeons should consider a fungal etiology in cases of cellulitis refractory to standard treatments in those patients with underlying immune dysfunction and/or in those receiving therapy with ruxolitinib or similar agents.

Keywords: cellulitis; fungal infection; infectious disease; janus kinase inhibitor; myelodysplasia; ruxolitinib.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Clinical photograph of patient’s leg prior to surgery.
Figure 2
Figure 2. Axial CT scan of the right tibia + fibula demonstrating an anterior tibial collection (red arrow).
See this image and copyright information in PMC

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