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. 2021:2:100101.
doi: 10.1016/j.sintl.2021.100101. Epub 2021 Jun 2.

Silver nanoparticle based multifunctional approach for combating COVID-19

Prince Allawadhi  1 , Vishakha Singh  2 , Amit Khurana  3   4   5 , Isha Khurana  6 , Sachin Allwadhi  7 , Pawan Kumar  8 , Anil Kumar Banothu  4   9 , Sunitha Thalugula  10 , Percy Jasmine Barani  11 , Ramavath Redya Naik  12 , Kala Kumar Bharani  5   9
Affiliations

Silver nanoparticle based multifunctional approach for combating COVID-19

Prince Allawadhi et al. Sens Int. 2021.

Abstract

COVID-19 is a highly contagious and widespread disease that has strained the global healthcare system to the hilt. Silver nanoparticles (AgNPs) are well known for their potent antimicrobial, antiviral, immunomodulatory and biosensing properties. AgNPs have been found to be potential antiviral agent that act against many deadly viruses and is presumed to be effective against COVID-19. AgNPs can generate free radicals and reactive oxygen species (ROS) leading to apoptosis mediated cell death thereby inhibiting viral infection. The shape and size of AgNPs play an important role in its biomedical applications as alterations may result in variable biological interaction and activity. Herein, we propose that AgNPs can be utilized for effective management of the ongoing COVID-19 pandemic by highlighting the current status of AgNPs in the fight against COVID-19.

Keywords: Antimicrobial; Antiviral activity; COVID-19; Cytokine storm; Silver nanoparticles.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Image 1
Graphical abstract
Fig. 1
Fig. 1
The life cycle of SARS CoV 2 inside the host. The figure was created with BioRender.com.
Fig. 2
Fig. 2
The mechanism of antibacterial activity of silver nanoparticles.
Fig. 3
Fig. 3
The mechanism of antiviral activity of silver nanoparticles.
Fig. 4
Fig. 4
The proposed mechanism of action of silver nanoparticles against COVID-19 induced lung injury and lung fibrosis. The figure was created with BioRender.com.
See this image and copyright information in PMC

References

    1. Li Q., et al. Early transmission dynamics in wuhan, China, of novel coronavirus–infected pneumonia. N. Engl. J. Med. 2020;382(13):1199–1207. - PMC - PubMed
    1. Schwartz D.A. An analysis of 38 pregnant women with COVID-19, their newborn infants, and maternal-fetal transmission of SARS-CoV-2: maternal coronavirus infections and pregnancy outcomes. Arch. Pathol. Lab Med. 2020;144(7):799–805. - PubMed
    1. Weiss S.R., Navas-Martin S. Coronavirus pathogenesis and the emerging pathogen severe acute respiratory syndrome coronavirus. Microbiol. Mol. Biol. Rev. 2005;69(4):635–664. - PMC - PubMed
    1. Belouzard S., et al. Mechanisms of coronavirus cell entry mediated by the viral spike protein. Viruses. 2012;4(6):1011–1033. - PMC - PubMed
    1. Zhou P., et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020;579(7798):270–273. - PMC - PubMed

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