Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2022 Feb;34(2):163-181.
doi: 10.1002/chir.23377. Epub 2021 Nov 11.

Chirality determination in crystals

Ángela Valentín-Pérez  1 , Patrick Rosa  1 , Elizabeth A Hillard  1   2 , Michel Giorgi  3
Affiliations
Review

Chirality determination in crystals

Ángela Valentín-Pérez et al. Chirality. 2022 Feb.

Abstract

This tutorial review article discusses chirality determination in the solid state, both in single crystals and in crystal assemblies, with an emphasis on X-ray diffraction. The main principles of using X-ray diffraction to reliably determine absolute structure are summarized, and the complexity which can be encountered in chiral structures-kryptoracemates, scalemates, and inversion twinning-is illustrated with examples from our laboratories and the literature. We then address the problem of the bulk crystallization and discuss different techniques to determine chirality in a large assembly of crystal structures, with a special prominence given to an X-ray natural circular dichroism mapping technique that we recently reported.

PubMed Disclaimer

References

REFERENCES

    1. Kuang H, Xu C, Tang Z. Emerging chiral materials. Adv Mater. 2020;32(41):2005110. https://doi.org/10.1002/adma.202005110
    1. Hwang M, Yeom B. Fabrication of chiral materials in nano- and microscale. Chem Mater. 2021;33(3):807-817. https://doi.org/10.1021/acs.chemmater.0c03846
    1. Kaminsky W, Claborn K, Kahr B. Polarimetric imaging of crystals. Chem Soc Rev. 2004;33(8):514-525.
    1. Kuroda R. Eng Cryst Mater Prop, Springer. 2008;251-270.
    1. Wenzel T, Wilcox J. Chiral reagents for the determination of enantiomeric excess and absolute configuration using NMR spectroscopy. Chirality. 2003;15(3):256-270.

LinkOut - more resources