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Meta-Analysis
. 2022 Feb;49(3):1021-1029.
doi: 10.1007/s00259-021-05616-5. Epub 2021 Nov 12.

68Ga-PSMA PET in prostate cancer: a systematic review and meta-analysis of the observer agreement

Mohammadreza Chavoshi  1 , Seyed Ali Mirshahvalad  2   3 , Ur Metser  4   5 , Patrick Veit-Haibach  4   5
Affiliations
Meta-Analysis

68Ga-PSMA PET in prostate cancer: a systematic review and meta-analysis of the observer agreement

Mohammadreza Chavoshi et al. Eur J Nucl Med Mol Imaging. 2022 Feb.

Abstract

Purpose: The performance of 68 Ga-PSMA PET/CT-MR has been evaluated in prostate cancer (PCa), showing significant results. However, even a technically accurate imaging procedure requires a high interobserver agreement in its interpretation to implement in patients' management. This study aims to perform a systematic review and meta-analysis on the interobserver variability in 68 Ga-PSMA PET/CT-MR imaging in PCa patients.

Methods: We conducted a systematic review and meta-analysis on the interobserver variability, including studies: (1) providing Kappa (K) as the inter-observer agreement test or the essential data to calculate it, (2) providing the K confidence interval or the essential crude data to calculate it, (3) measuring K statistic based on the appropriate use criteria for the inter-observer agreement.

Results: Twelve studies, providing 1585 68 Ga-PSMA PET/CT-MR studies reviewed by 62 independent readers, were included. In general, the pooled inter-observer agreement was interpreted as substantial for all analyzed groups, including tumoral lesions in the prostate bed, lymphadenopathies, bone metastasis, and soft-tissue metastasis (all between 0.6 and 0.8). The regional lymphadenopathy group (0.74) obtained the highest agreement, while the lowest was for soft tissue metastasis (0.65).

Conclusion: This study showed a substantial interobserver agreement in the overall interpretation and detecting locoregional and distant involvement with 68 Ga-PSMA PET/CT-MR in PCa patients.

Keywords: Agreement; Meta-analysis; PET; PSMA; Variability.

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