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Review
. 2022 Mar;179(6):1125-1145.
doi: 10.1111/bph.15724. Epub 2022 Jan 13.

Sordarin- An anti-fungal antibiotic with a unique modus operandi

Yutian Shao  1   2 , Eliza Molestak  2 , Weike Su  1   3   4 , Marek Stankevič  5 , Marek Tchórzewski  2
Affiliations
Free article
Review

Sordarin- An anti-fungal antibiotic with a unique modus operandi

Yutian Shao et al. Br J Pharmacol. 2022 Mar.
Free article

Abstract

Fungal infections cause serious problems in many aspects of human life, in particular infections in immunocompromised patients present serious problems. Current anti-fungal antibiotics target various metabolic pathways, predominantly the cell wall or cellular membrane metabolism. Numerous compounds are available to combat fungal infections, but their efficacy is far from satisfactory and some of them display high toxicity. The emerging antibiotic resistance represents a serious issue as well. Hence, there is a considerable need for new anti-fungal compounds with lower toxicity and higher effectiveness. One of the unique anti-fungal antibiotics is sordarin, the only known compound that acts on the fungal translational machinery per se. Sordarin inhibits protein synthesis at the elongation step of the translational cycle, acting on eukaryotic translation elongation factor 2. In this review, we deliver a robust scientific platform promoting the development of anti-fungal compounds, in particular focusing on the molecular action of sordarin.

Keywords: eukaryotic translation elongation factor - EEF2 (eEF2); ribosome; sordarin; translation; translational GTPase; translocation.

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References

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