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Review
. 2022 Feb;69(2):e29442.
doi: 10.1002/pbc.29442. Epub 2021 Nov 12.

Current approaches to management of bone sarcoma in adolescent and young adult patients

Katrina M Ingley  1 , Alessandra Maleddu  1 , Franel Le Grange  1 , Craig Gerrand  2 , Archie Bleyer  3 , Ephia Yasmin  4 , Jeremy Whelan  1 , Sandra J Strauss  1   5
Affiliations
Review

Current approaches to management of bone sarcoma in adolescent and young adult patients

Katrina M Ingley et al. Pediatr Blood Cancer. 2022 Feb.

Abstract

Bone tumors are a group of histologically diverse diseases that occur across all ages. Two of the commonest, osteosarcoma (OS) and Ewing sarcoma (ES), are regarded as characteristic adolescent and young adult (AYA) cancers with an incidence peak in AYAs. They are curable for some but associated with unacceptably high rates of treatment failure and morbidity. The introduction of effective new therapeutics for bone sarcomas is slow, and to date, complex biology has been insufficiently characterized to allow more rapid therapeutic exploitation. This review focuses on current standards of care, recent advances that have or may soon change that standard of care and challenges to the expert clinical research community that we suggest must be met.

Keywords: Ewing sarcoma; adolescent and young adult (AYA); bone sarcoma; clinical trials; local control; osteosarcoma; radiation; surgery.

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References

REFERENCES

    1. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2020. CA Cancer J Clin. 2020;70:7-30.
    1. Surveillance, Epidemiology, and End Results (SEER) Program (www.seer.cancer.gov) SEER*Stat Database: Incidence- SEER Research Limited-Field DATA, 21 Registries, Nov 2020 Sub (2000-2018)-Linked to County Attributes-Time Dependent (1990-2018)-Income/Rurality, 1969-2019 Counties, National Cancer Institute, DCCPS, Surveillance Research Program, released April 2021, based on the November 2020 submission.
    1. Amadeo B, Penel N, Coindre JM, et al. Incidence and time trends of sarcoma (2000-2013): results from the French network of cancer registries (FRANCIM). BMC Cancer. 2020;20:190.
    1. Gatta G, Capocaccia R, Botta L, et al. Burden and centralised treatment in Europe of rare tumours: results of RARECAREnet-a population-based study. Lancet Oncol. 2017;18:1022-1039.
    1. Whelan J, McTiernan A, Cooper N, et al. Incidence and survival of malignant bone sarcomas in England 1979-2007. Int J Cancer. 2012;131:E508-517.

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