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Comment
. 2021 Dec 13;39(12):1562-1564.
doi: 10.1016/j.ccell.2021.11.001. Epub 2021 Nov 11.

Immune activation and evolution through chemotherapy plus checkpoint blockade in triple-negative breast cancer

Siang-Boon Koh  1 , Leif W Ellisen  2
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Immune activation and evolution through chemotherapy plus checkpoint blockade in triple-negative breast cancer

Siang-Boon Koh et al. Cancer Cell. .
Free article

Abstract

Immune checkpoint blockade plus chemotherapy is emerging as a standard treatment for some patients with triple-negative breast cancer (TNBC). In this issue of Cancer Cell, Zhang et al. employ extensive single-cell immune compartment analyses of pre- and post-therapy TNBC, and they reveal potential mechanisms of T cell activation and patterns of immune evolution that may inform future biomarkers of response and clinical benefit.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

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