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Comment
. 2021 Nov 11;184(23):5691-5693.
doi: 10.1016/j.cell.2021.10.012.

Cyclic pyrimidines jump on the anti-phage bandwagon

Karen L Maxwell  1
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Free article
Comment

Cyclic pyrimidines jump on the anti-phage bandwagon

Karen L Maxwell. Cell. .
Free article

Abstract

Cyclic pyrimidines cCMP and cUMP were known to be present in a variety of organisms and cell types, but their biological roles remained mysterious. Tal et al. show that bacteria use cCMP and cUMP as second messengers that function in anti-phage defense.

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  • Cyclic CMP and cyclic UMP mediate bacterial immunity against phages.
    Tal N, Morehouse BR, Millman A, Stokar-Avihail A, Avraham C, Fedorenko T, Yirmiya E, Herbst E, Brandis A, Mehlman T, Oppenheimer-Shaanan Y, Keszei AFA, Shao S, Amitai G, Kranzusch PJ, Sorek R. Tal N, et al. Cell. 2021 Nov 11;184(23):5728-5739.e16. doi: 10.1016/j.cell.2021.09.031. Epub 2021 Oct 12. Cell. 2021. PMID: 34644530 Free PMC article.

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