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Comment
. 2021 Nov 11;184(23):5693-5695.
doi: 10.1016/j.cell.2021.10.019.

Morpholinos meet mitochondria: Targeting organellar gene expression

Heike Rampelt  1 , Nikolaus Pfanner  2
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Morpholinos meet mitochondria: Targeting organellar gene expression

Heike Rampelt et al. Cell. .
Free article

Abstract

The mitochondrial genome encodes proteins central to mitochondrial function; however, transcript-specific mechanistic studies of mitochondrial gene products have been difficult because of challenges in their experimental manipulation. Cruz-Zaragoza et al. provide a solution to this challenge, introducing an elegant system for efficient translational silencing of transcripts in human mitochondria.

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  • An in vitro system to silence mitochondrial gene expression.
    Cruz-Zaragoza LD, Dennerlein S, Linden A, Yousefi R, Lavdovskaia E, Aich A, Falk RR, Gomkale R, Schöndorf T, Bohnsack MT, Richter-Dennerlein R, Urlaub H, Rehling P. Cruz-Zaragoza LD, et al. Cell. 2021 Nov 11;184(23):5824-5837.e15. doi: 10.1016/j.cell.2021.09.033. Epub 2021 Oct 20. Cell. 2021. PMID: 34672953

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