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Comment
. 2021 Nov 11;184(23):5696-5698.
doi: 10.1016/j.cell.2021.10.018.

A lymphocyte-glia connection sets the pace for smoldering inflammation

Stefan Bittner  1 , Frauke Zipp  2
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A lymphocyte-glia connection sets the pace for smoldering inflammation

Stefan Bittner et al. Cell. .
Free article

Abstract

Successful therapeutic options directly targeting disability progression in patients with multiple sclerosis (MS), a chronic inflammatory disorder of the central nervous system, are lacking. Now, a study published in Nature by Absinta and colleagues profiles a lymphocyte-glia connection at the edge of chronic active lesions that continuously drives neurodegenerative pathways.

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  • A lymphocyte-microglia-astrocyte axis in chronic active multiple sclerosis.
    Absinta M, Maric D, Gharagozloo M, Garton T, Smith MD, Jin J, Fitzgerald KC, Song A, Liu P, Lin JP, Wu T, Johnson KR, McGavern DB, Schafer DP, Calabresi PA, Reich DS. Absinta M, et al. Nature. 2021 Sep;597(7878):709-714. doi: 10.1038/s41586-021-03892-7. Epub 2021 Sep 8. Nature. 2021. PMID: 34497421 Free PMC article.

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