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. 2021 Oct 29;10(21):5057.
doi: 10.3390/jcm10215057.

Thyroid Disfunction in Critically Ill COVID-19 Patients. Relationship with In-Hospital Mortality

María Antonieta Ballesteros Vizoso  1 , Albert Figueras Castilla  2 , Antonia Barceló  1   3 , Joan Maria Raurich  2 , Paula Argente Del Castillo  1 , Daniel Morell-García  1   3 , Julio Velasco  2 , Jon Pérez-Bárcena  2   3 , Juan Antonio Llompart-Pou  2   3
Affiliations

Thyroid Disfunction in Critically Ill COVID-19 Patients. Relationship with In-Hospital Mortality

María Antonieta Ballesteros Vizoso et al. J Clin Med. .

Abstract

The incidence of thyroid disfunction has not been analyzed in critically ill COVID-19 patients. Our objective was to analyze the relationship of the thyroid profile and in-hospital mortality in critically ill COVID-19 patients. This was a prospective single-center study involving critically ill COVID-19 patients admitted to the ICU of a tertiary University Hospital. Thyroid hormones were measured through drawing blood samples from a central venous catheter at ICU admission and on the fifth day. A multiple logistic regression analysis was performed to analyze the variables associated with mortality. The ability of the different thyroid hormones to predict in-hospital mortality was evaluated by calculating the receiver operating characteristics (ROCs) and the area under the curve (AUC). A total of 78 patients were included in the study at ICU admission; 72 had their thyroid profile measured at day 5. In-hospital mortality reached 29.5%. Multiple logistic regression analysis showed that variables associated with mortality were age and prior beta-blocker therapy at ICU admission and age fT4 at day 5. The AUC for in-hospital mortality predictions of fT4 at day 5 was 0.69. Thyroid responses are commonly observed in critically ill COVID-19 patients. fT4 at day 5 after ICU admission was associated with mortality.

Keywords: COVID-19; critically ill patients; intensive care unit; mortality; thyroid hormones.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Changes in the thyroid profile over time in survivors (left) and non-survivors (right). *: p< 0.05.
Figure 2
Figure 2
Receiver operating characteristic (ROC) curves of thyroid hormones at ICU admission and day 5 to predict in-hospital mortality.
See this image and copyright information in PMC

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