Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Oct 25;22(21):11500.
doi: 10.3390/ijms222111500.

Delphinidin and Its Glycosides' War on Cancer: Preclinical Perspectives

Anshul Sharma  1 , Hyo-Kyoung Choi  2 , Yeon-Kye Kim  3 , Hae-Jeung Lee  1   4
Affiliations
Review

Delphinidin and Its Glycosides' War on Cancer: Preclinical Perspectives

Anshul Sharma et al. Int J Mol Sci. .

Abstract

Until now, several studies have looked at the issue of anthocyanin and cancer, namely the preventive and inhibitory effects of anthocyanins, as well as the underlying molecular processes. However, no targeted review is available regarding the anticarcinogenic effects of delphinidin and its glycosides on various cancers and their plausible molecular mechanisms. Considerable evidence shows significant anticancer properties of delphinidin-rich preparations and delphinidin alone both in vitro and in vivo. This review covers the in vitro and preclinical implications of delphinidin-mediated cell protection and cancer prevention; thus, we strongly recommend that delphinidin-rich preparations be further investigated as potential functional food, dietary antioxidant supplements, and natural health products targeting specific chronic diseases, including cancer. In addition to in vitro investigations, future research should focus on more animal and human studies to determine the true potential of delphinidin.

Keywords: anthocyanidins; anthocyanins; cancer; delphinidin; metastasis; proliferation.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Chemical representation of delphinidin and its glycosides. R = H (delphinidin), R = glucoside (delphinidin-3-O-glucoside), R = galactoside (delphinidin-3-O-galactoside), R = rutinoside (delphinidin-3-O-rutinoside), R = arabinoside, (delphinidin-3-O-arabinoside), and R = sambubioside (delphinidin-3-O-sambubioside).
Figure 2
Figure 2
Plausible chemotherapeutic and chemopreventive working mechanisms of delphinidin and its glycosides [14,20,21,22,24,25,26,28,29,30,31,32].
See this image and copyright information in PMC

References

    1. Pieńkowska N., Bartosz G., Furdak P., Sadowska-Bartosz I. Delphinidin Increases the Sensitivity of Ovarian Cancer Cell Lines to 3-Bromopyruvate. Int. J. Mol. Sci. 2021;22:709. doi: 10.3390/ijms22020709. - DOI - PMC - PubMed
    1. Chen J., Xu B., Sun J., Jiang X., Bai W. Anthocyanin supplement as a dietary strategy in cancer prevention and management: A comprehensive review. Crit. Rev. Food Sci. Nutr. 2021:1–13. doi: 10.1080/10408398.2021.1913092. - DOI - PubMed
    1. Hair R., Sakaki J., Chun O. Anthocyanins, Microbiome and Health Benefits in Aging. Molecules. 2021;26:537. doi: 10.3390/molecules26030537. - DOI - PMC - PubMed
    1. Castañeda-Ovando A., de Lourdes Pacheco-Hernández M., Páez-Hernández M.E., Rodríguez J.A., Galán-Vidal C.A. Chemical studies of anthocyanins: A review. Food Chem. 2009;113:859–871. doi: 10.1016/j.foodchem.2008.09.001. - DOI
    1. Ozbay T., Nahta R. Delphinidin inhibits HER2 and Erk1/2 signaling and suppresses growth of HER2-overexpressing and triple negative breast cancer cell lines. Breast Cancer Basic Clin. Res. 2011;5:143–154. doi: 10.4137/BCBCR.S7156. - DOI - PMC - PubMed