Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Nov 3;22(21):11924.
doi: 10.3390/ijms222111924.

Erythrocyte Deformability and Na,K-ATPase Activity in Various Pathophysiological Situations and Their Protection by Selected Nutritional Antioxidants in Humans

Jana Radosinska  1   2 , Norbert Vrbjar  2
Affiliations
Review

Erythrocyte Deformability and Na,K-ATPase Activity in Various Pathophysiological Situations and Their Protection by Selected Nutritional Antioxidants in Humans

Jana Radosinska et al. Int J Mol Sci. .

Abstract

The physicochemical and functional properties of erythrocytes are worsened in a variety of diseases. Erythrocyte deformability refers to their ability to adjust their shape according to external forces exerted against them in the circulation. It is influenced by the functionality of the Na,K-ATPase enzyme, which is localized in their membranes. The proposed review is focused on knowledge regarding changes in erythrocyte Na,K-ATPase activity, and their impact on erythrocyte deformability in various pathophysiological situations observed exclusively in human studies, as well as on the potential erytroprotective effects of selected natural nutritional antioxidants. A clear link between the erythrocyte properties and the parameters of oxidative stress was observed. The undesirable consequences of oxidative stress on erythrocyte quality and hemorheology could be at least partially prevented by intake of diverse antioxidants occurring naturally in foodstuffs. Despite intensive research concerning the effect of antioxidants, only a small number of investigations on erythrocyte properties in humans is available in databases. It is worth shifting attention from animal and in vitro experiments and focusing more on antioxidant administration in human studies in order to establish what type of antioxidant, in what concentration, and in which individuals it may provide a beneficial effect on the human organism, by protecting erythrocyte properties.

Keywords: Na,K-ATPase; antioxidants; deformability; erythrocytes; hemorheology; human RBC; human studies; pathophysiology; phenolic compounds; vitamins.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest. The funder had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.

References

    1. Barshtein G., Pries A.R., Goldschmidt N., Zukerman A., Orbach A., Zelig O., Arbell D., Yedgar S. Deformability of transfused red blood cells is a potent determinant of transfusion-induced change in recipient’s blood flow. Microcirculation. 2016;23:479–486. doi: 10.1111/micc.12296. - DOI - PubMed
    1. Kazennov A.M., Maslova M.N., Shalabodov A.D., Bagrov J.Y., Gurevich V.S. Some properties of erythrocyte Na+-K+-ATPase in essential hypertension. Clin. Exp. Hypertension. Part A Theory Pract. 1987;9:1221–1232. doi: 10.3109/10641968709160045. - DOI - PubMed
    1. Kazennov A.M., Ul’ianova T.P., Ganelina I.E., Gusev G.P., Kruchinina N.A., Maslova M.N. Ionnyĭ gomeostaz i deformiruemost’ éritrotsitov u bolnykh s pervichnoĭ arterial’noĭ gipertenzieĭ [Ionic homeostasis and erythrocyte deformability in patients with primary arterial hypertension] Kardiologiia. 1990;30:19–22. - PubMed
    1. David-Dufilho M., Astarie C., Pernollet M.G., Del Pino M., Levenson J., Simon A., Devynck M.A. Control of the erythrocyte free Ca2+ concentration in essential hypertension. Hypertension. 1992;19:167–174. doi: 10.1161/01.HYP.19.2.167. - DOI - PubMed
    1. Cicco G., Carbonara M.C., Stingi G.D., Pirrelli A. Cytosolic calcium and hemorheological patterns during arterial hypertension. Clin. Hemorheol. Microcirc. 2001;24:25–31. - PubMed

MeSH terms

Substances