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. 2021 Oct 31;26(21):6611.
doi: 10.3390/molecules26216611.

Phenylalanine Butyramide Is a New Cosmetic Ingredient with Soothing and Anti-Reddening Potential

Ritamaria di Lorenzo  1 , Antonietta Bernardi  1 , Lucia Grumetto  1 , Antonia Sacchi  1 , Carmen Avagliano  1 , Serena Coppola  2   3 , Anna Fiorenza de Giovanni di Santa Severina  2   3 , Cristina Bruno  2   3 , Lorella Paparo  2   3 , Sonia Laneri  1 , Irene Dini  1
Affiliations

Phenylalanine Butyramide Is a New Cosmetic Ingredient with Soothing and Anti-Reddening Potential

Ritamaria di Lorenzo et al. Molecules. .

Abstract

Human skin is colonized by diverse commensal microbes, making up the skin microbiota (SM), contributing to skin integrity and homeostasis. Many of the beneficial effects aroused by the SM are exerted by microbial metabolites such as short-chain fatty acids (SCFAs), including butyric acid. The SCFAs can be used in cosmetic formulations against skin diseases to protect SM by preserving and/or restoring their natural balance. Unpleasant sensorial properties and unfavorable physico-chemical properties of butyrate strongly limit its cosmetic use. In contrast, some butyrate derivatives, including phenylalanine butyramide (C13H18N2O2, FBA), a solid form of butyric acid, are odorless while retaining the pharmacokinetic properties and safety profile of butyric acid. This study assessed the FBA's permeation across the skin and its soothing and anti-reddening potential to estimate its cosmetic application. The dosage method used to estimate FBA's levels was validated to be sure of analytical results. The FBA diffusion tests were estimated in vitro using a Franz-type vertical diffusion cell. The soothing action was evaluated in vivo by Colorimeter CL400, measuring the erythema index. The results suggest that the FBA represents an innovative way to exploit the benefits of butyric acid in the cosmetic fields since it cannot reach the bloodstream, is odorless, and has a significative soothing action (decrease the erythema index -15.7% after 30', and -17.8% after 60').

Keywords: butyrate; erythema index; skin microbiota; skin permeation; soothing and anti-reddening effect.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Phenylalanine butyramide (FBA).
Figure 2
Figure 2
Chromatograms related to the determination of FBA levels in the skin.
Figure 3
Figure 3
Image of the three test sites identified on the volunteer’s forearm at T1h.
See this image and copyright information in PMC

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