COVID-19 Presentation and Outcomes among Cancer Patients: A Matched Case-Control Study

Julien Péron^{1

2

3}, Tristan Dagonneau⁴, Anne Conrad^{5

6}, Fanny Pineau⁷, Sara Calattini⁷, Gilles Freyer^{1

3}, David Perol⁸, Christophe Sajous^{1

3}, Maël Heiblig^{3

9}

Affiliations

¹ Medical Oncology Department, Institut de Cancérologie des Hospices Civils de Lyon, 69002 Lyon, France.
² Laboratoire de Biométrie et Biologie Evolutive, Equipe Biostatistique-Santé, CNRS UMR 5558, Université Claude Bernard Lyon 1, 69100 Villeurbanne, France.
³ Faculté de Médecine et de Maïeutique Lyon-Sud-Charles Mérieux, Université Claude Bernard Lyon 1, 69310 Pierre-Bénite, France.
⁴ Medical Information Department, Hospices Civils de Lyon, 69002 Lyon, France.
⁵ Infectious Diseases Department, Croix-Rousse Hospital, 69004 Lyon, France.
⁶ Centre International de Recherche en Infectiologie (CIRI), Inserm U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, Ecole Normale Supérieure de Lyon, University of Lyon, 69007 Lyon, France.
⁷ Clinical Research Plateform, Institut de Cancérologie des Hospices Civils de Lyon, 69002 Lyon, France.
⁸ Centre Léon Bérard, 69008 Lyon, France.
⁹ Haematology Department, Institut de Cancérologie des Hospices Civils de Lyon, 69310 Pierre-Bénite, France.

PMID: 34771446
PMCID: PMC8582532
DOI: 10.3390/cancers13215283

COVID-19 Presentation and Outcomes among Cancer Patients: A Matched Case-Control Study

Julien Péron et al. Cancers (Basel). 2021.

. 2021 Oct 21;13(21):5283.

doi: 10.3390/cancers13215283.

Authors

Julien Péron^{1

2

3}, Tristan Dagonneau⁴, Anne Conrad^{5

6}, Fanny Pineau⁷, Sara Calattini⁷, Gilles Freyer^{1

3}, David Perol⁸, Christophe Sajous^{1

3}, Maël Heiblig^{3

9}

Affiliations

¹ Medical Oncology Department, Institut de Cancérologie des Hospices Civils de Lyon, 69002 Lyon, France.
² Laboratoire de Biométrie et Biologie Evolutive, Equipe Biostatistique-Santé, CNRS UMR 5558, Université Claude Bernard Lyon 1, 69100 Villeurbanne, France.
³ Faculté de Médecine et de Maïeutique Lyon-Sud-Charles Mérieux, Université Claude Bernard Lyon 1, 69310 Pierre-Bénite, France.
⁴ Medical Information Department, Hospices Civils de Lyon, 69002 Lyon, France.
⁵ Infectious Diseases Department, Croix-Rousse Hospital, 69004 Lyon, France.
⁶ Centre International de Recherche en Infectiologie (CIRI), Inserm U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, Ecole Normale Supérieure de Lyon, University of Lyon, 69007 Lyon, France.
⁷ Clinical Research Plateform, Institut de Cancérologie des Hospices Civils de Lyon, 69002 Lyon, France.
⁸ Centre Léon Bérard, 69008 Lyon, France.
⁹ Haematology Department, Institut de Cancérologie des Hospices Civils de Lyon, 69310 Pierre-Bénite, France.

PMID: 34771446
PMCID: PMC8582532
DOI: 10.3390/cancers13215283

Abstract

It has been suggested that cancer patients are at higher risk of contracting COVID-19 and at higher risk of developing a severe form of the disease and fatality. This study's objectives were to measure the excess risk of mortality and morbidity of patients with cancer among patients hospitalized for a SARS-CoV-2 infection, and to identify factors associated with the risk of death and morbidity among cancer patients. All first cancer patients hospitalized for COVID-19 in the two main hospitals of the Lyon area were included. These patients were matched based on age, gender, and comorbidities with non-cancer control patients. A total of 108 cancer patients and 193 control patients were included. The severity at admission and the symptoms were similar between the two groups. The risk of early death was higher among cancer patients, while the risk of intubation, number of days with oxygen, length of stay in ICU, and length of hospital stay were reduced. The main factors associated with early death among cancer patients was the severity of COVID-19 and the number of previous chemotherapy lines. The outcomes appear to be driven by the severity of the infection and therapeutic limitations decided at admission.

Keywords: COVID-19; cancer; matched cohort study; mortality; prognosis.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

**Figure 1**
Overall survival from hospital admission among cancer patients and matched controls.

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COVID-19 Presentation and Outcomes among Cancer Patients: A Matched Case-Control Study

Affiliations

COVID-19 Presentation and Outcomes among Cancer Patients: A Matched Case-Control Study

Authors

Affiliations

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Conflict of interest statement

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