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Review
. 2021 Oct 21;13(21):5288.
doi: 10.3390/cancers13215288.

The Risk of Malignancies in Celiac Disease-A Literature Review

Filippo Pelizzaro  1 , Ilaria Marsilio  1 , Matteo Fassan  2   3 , Francesco Piazza  4 , Brigida Barberio  1 , Anna D'Odorico  1 , Edoardo V Savarino  1 , Fabio Farinati  1 , Fabiana Zingone  1
Affiliations
Review

The Risk of Malignancies in Celiac Disease-A Literature Review

Filippo Pelizzaro et al. Cancers (Basel). .

Abstract

Celiac disease (CeD) is an immune-mediated enteropathy precipitated by ingestion of gluten in genetically predisposed individuals. Considering that CeD affects approximately 1% of the Western population, it may be considered a global health problem. In the large majority of cases, CeD has a benign course, characterized by the complete resolution of symptoms and a normal life expectancy after the beginning of a gluten-free-diet (GFD); however, an increased risk of developing malignancies, such as lymphomas and small bowel carcinoma (SBC), has been reported. In particular, enteropathy-associated T-cell lymphoma (EATL), a peculiar type of T-cell lymphoma, is characteristically associated with CeD. Moreover, the possible association between CeD and several other malignancies has been also investigated in a considerable number of studies. In this paper, we aim to provide a comprehensive review of the current knowledge about the associations between CeD and cancer, focusing in particular on EATL and SBC, two rare but aggressive malignancies.

Keywords: carcinoma; celiac disease; complication; lymphoma; malignancy; tumor.

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Conflict of interest statement

The authors declare no conflict of interest.

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