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Review
. 2021 Oct 22;14(21):6319.
doi: 10.3390/ma14216319.

Metal Nanoparticles and Carbon-Based Nanomaterials for Improved Performances of Electrochemical (Bio)Sensors with Biomedical Applications

Affiliations
Review

Metal Nanoparticles and Carbon-Based Nanomaterials for Improved Performances of Electrochemical (Bio)Sensors with Biomedical Applications

Luminita Fritea et al. Materials (Basel). .

Abstract

Monitoring human health for early detection of disease conditions or health disorders is of major clinical importance for maintaining a healthy life. Sensors are small devices employed for qualitative and quantitative determination of various analytes by monitoring their properties using a certain transduction method. A "real-time" biosensor includes a biological recognition receptor (such as an antibody, enzyme, nucleic acid or whole cell) and a transducer to convert the biological binding event to a detectable signal, which is read out indicating both the presence and concentration of the analyte molecule. A wide range of specific analytes with biomedical significance at ultralow concentration can be sensitively detected. In nano(bio)sensors, nanoparticles (NPs) are incorporated into the (bio)sensor design by attachment to the suitably modified platforms. For this purpose, metal nanoparticles have many advantageous properties making them useful in the transducer component of the (bio)sensors. Gold, silver and platinum NPs have been the most popular ones, each form of these metallic NPs exhibiting special surface and interface features, which significantly improve the biocompatibility and transduction of the (bio)sensor compared to the same process in the absence of these NPs. This comprehensive review is focused on the main types of NPs used for electrochemical (bio)sensors design, especially screen-printed electrodes, with their specific medical application due to their improved analytical performances and miniaturized form. Other advantages such as supporting real-time decision and rapid manipulation are pointed out. A special attention is paid to carbon-based nanomaterials (especially carbon nanotubes and graphene), used by themselves or decorated with metal nanoparticles, with excellent features such as high surface area, excellent conductivity, effective catalytic properties and biocompatibility, which confer to these hybrid nanocomposites a wide biomedical applicability.

Keywords: biomedical applications; carbon-based nanomaterials; electrochemical (bio)sensors; metal nanoparticles; screen-printed electrodes.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Microscopic images of some metal nanoparticles (1a—SEM image of TiO2 NPs, 1b—SEM image of TiO2 doped with SeNPs; 2a—TEM image of SeNPS; 2b—AFM image of SeNPs; 3a—SEM image of AuNPs, 3b—AFM image of AuNPs), carbon-based nanomaterials (4a—SEM image of MWCNTs, 4b—AFM image of MWCNTs; 5a—SEM image of graphene, 5b—AFM image of graphene) and hybrid nanocomposite (6a—SEM image of graphene + AuNPs, 6b—AFM image of graphene + AuNPs) (original images).
Figure 2
Figure 2
Schematic representation of main synthesis methods of metal NPs and carbon-based nanomaterials.
Figure 3
Figure 3
Some examples of commercially available screen-printed electrodes (from different manufacturers: https://www.dropsens.com/en/screen_printed_electrodes_pag.html; https://www.palmsens.com/products/sensors/screen-printed-electrodes/, accessed 10 September 2021).
Figure 4
Figure 4
Schematic representation of nano(bio)sensors based on screen-printed electrodes: modification with carbon-based nanomaterials, metal nanoparticles, with/without biological elements and the electrochemical analysis.

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