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. 2021 Dec;42(12):1066-1068.
doi: 10.1016/j.it.2021.10.014. Epub 2021 Nov 9.

Locked and loaded: strong TCR signaling primes anti-PD-1 therapy

Kristina Correa  1 , Michael L Dustin  2
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Locked and loaded: strong TCR signaling primes anti-PD-1 therapy

Kristina Correa et al. Trends Immunol. 2021 Dec.

Abstract

With continuous T cell receptor (TCR) signaling, T cells can attenuate subsequent antigen responses through adaptive tolerance, thus averting autoimmunity, but potentially also providing refuge to developing cancers. Elliot and coworkers add to our understanding of adaptation via immune checkpoints by exploiting accelerated in vivo adaptive tolerance in the face of strong TCR signaling.

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Conflict of interest statement

Declaration of interests The authors declare no conflict of interest.

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