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Review
. 2022 May;36(5):488-492.
doi: 10.1038/s41371-021-00636-y. Epub 2021 Nov 12.

Bioengineered angiotensin-converting-enzyme-2: a potential therapeutic option against SARS-CoV-2 infection

Biplab K Maiti  1
Affiliations
Review

Bioengineered angiotensin-converting-enzyme-2: a potential therapeutic option against SARS-CoV-2 infection

Biplab K Maiti. J Hum Hypertens. 2022 May.

Abstract

The recombinant soluble human angiotensin-converting enzyme 2 (rshACE2) is a promising therapy against SARS-CoV-2 infection, but it has some drawbacks that reduce the success of its clinical applications. The bioengineered ACE2 (Tag-sACE2 and probiotic-ACE2) as a way may overcome its therapeutic limitations against ongoing current pandemic.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1. Dual role of ACE2.
Cartoon represents the dual role of ACE2:virus receptor domain (dark black color ribbon) and lung protector catalytic Zn-site (black dotted circle). The ACE2 structure is adopted from PDB-1R42.
Fig. 2
Fig. 2. ACE2 shedding and virus entry & spreading in cell.
Cartoon represents the proposed ACE2 shedding and SARS-CoV-2 entry as well as randomly circulating sACE2-ASRS-CoV-2 complex in extracellular space.
Fig. 3
Fig. 3. Bioengineered ACE2: Panel A - rsACE2, Panel B - Tag-rsACE2 and Panel C - Probiotic-ACE2.
Probable designed ACE2 for disruption of mACE2-viral interlock: rhACE2 (A), tag-rsACE2 (B), and expression of mACE2 in probiotic (C).
See this image and copyright information in PMC

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