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. 2021:1344:169-188.
doi: 10.1007/978-3-030-81147-1_10.

The Reciprocal Interaction Between Sleep and Alzheimer's Disease

Samuel S Harris  1 , Tom Schwerd-Kleine  1 , Byung Il Lee  1 , Marc Aurel Busche  2
Affiliations

The Reciprocal Interaction Between Sleep and Alzheimer's Disease

Samuel S Harris et al. Adv Exp Med Biol. 2021.

Abstract

It is becoming increasingly recognized that patients with a variety of neurodegenerative diseases exhibit disordered sleep/wake patterns. While sleep impairments have typically been thought of as sequelae of underlying neurodegenerative processes in sleep-wake cycle regulating brain regions, including the brainstem, hypothalamus, and basal forebrain, emerging evidence now indicates that sleep deficits may also act as pathophysiological drivers of brain-wide disease progression. Specifically, recent work has indicated that impaired sleep can impact on neuronal activity, brain clearance mechanisms, pathological build-up of proteins, and inflammation. Altered sleep patterns may therefore be novel (potentially reversible) dynamic functional markers of proteinopathies and modifiable targets for early therapeutic intervention using non-invasive stimulation and behavioral techniques. Here we highlight research describing a potentially reciprocal interaction between impaired sleep and circadian patterns and the accumulation of pathological signs and features in Alzheimer's disease, the most prevalent neurodegenerative disease in the elderly.

Keywords: Alzheimer’s disease; Amyloid-beta; Clinical; Learning and memory; Sleep impairment; Sleep-wake cycle; Slow-wave sleep; Tau; Translational.

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