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Review
. 2021 Dec;48(4):761-782.
doi: 10.1016/j.clp.2021.07.006. Epub 2021 Oct 2.

Nasal High-Frequency Ventilation

Daniele De Luca  1 , Roberta Centorrino  2
Affiliations
Review

Nasal High-Frequency Ventilation

Daniele De Luca et al. Clin Perinatol. 2021 Dec.

Abstract

Noninvasive high-frequency oscillatory (NHFOV) and percussive (NHFPV) ventilation represent 2 nonconventional techniques that may be useful in selected neonatal patients. We offer here a comprehensive review of physiology, mechanics, and biology for both techniques. As NHFOV is the technique with the wider experience, we also provided a meta-analysis of available clinical trials, suggested ventilatory parameters boundaries, and proposed a physiology-based clinical protocol to use NHFOV.

Keywords: Interface; Neonate; Newborn infant; Noninvasive; Oscillation; Percussive; Rescue; Respiratory support.

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Conflict of interest statement

Conflicts of interest Prof. D. De Luca has received research grants, technical assistance, and travel grants from Vyaire Inc. He also served as a lecturer for Getinge Inc. Dr R. Centorrino received a travel grant from Vyaire Inc. These companies produce ventilators that are able to provide noninvasive high-frequency ventilations but had no role in the conception, writing, or decision to submit this article.