Giant pulmonary hamartoma with placental transmogrification-a case report

Abstract

Pulmonary hamartomas are rare tumors and are mostly found incidentally in patients investigated for other pathologies. They are frequently small in size, though with some being reported as large as 25 centimeters (cm). We are reporting a case of a huge pulmonary hamartoma (measuring 25.5 × 17.5 × 15.5 cm and weighing about 2200 grams (g)) in a 33-year-old lady with a short duration history of breathlessness. The tumor had origin from the medial border of the left lung, extending into almost the entire left hemithorax and partly into the anterior mediastinum, with no local invasion. The left lower lobe had compression atelectasis due to mass. The mass was successfully resected. The histopathology report showed predominant adipose tissue and cartilaginous differentiation. There were also a few foci of papillary projections with predominant vascular areas, resembling immature placental villi, suggestive of placental transmogrification of the mass.

Keywords: Giant pulmonary hamartoma; Placental transmogrification.

Fig. 1

Chest radiography of the patient demonstrating a mass in the left chest

Fig. 2

Tumor dissection and en bloc removal. On histopathological examination, few foci of papillary projections were seen resembling immature placental villi, suggestive of placental transmogrification of the lung mass