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Meta-Analysis
. 2021 Nov 3:2021:1758066.
doi: 10.1155/2021/1758066. eCollection 2021.

Tranexamic Acid versus Epsilon-Aminocaproic Acid in Total Knee Arthroplasty: A Meta-Analysis

Zhihui Li  1 , Xiaotong Sun  2 , Weihua Li  1 , Minghui Zhang  1
Affiliations
Meta-Analysis

Tranexamic Acid versus Epsilon-Aminocaproic Acid in Total Knee Arthroplasty: A Meta-Analysis

Zhihui Li et al. J Healthc Eng. .

Retraction in

Abstract

Objective: At present, the effect of tranexamic acid (TXA) and epsilon-aminocaproic acid (EACA) on total knee arthroplasty (TKA) remains controversial. Therefore, the aim of this meta-analysis is to compare the differences between the effects of TXA and EACA in TKA.

Methods: We used electronic databases, including PubMed, Embase, MEDLINE, Ovid, ScienceDirect, Cochran Library, Google Scholar, clinical trial, and Chinese related databases, for literature search to find any effect of TXA and EACA in TKA. The differences between groups were compared by odds ratio (OR), weighted mean difference (WMD), and 95% confidence interval (CI). A total of four studies, including 3 randomized controlled trials (RCT) and 1 cohort study, were involved in this meta-analysis, involving 1836 participants. Among these participants, 816 belonged to the TXA group and 1020 belonged to the EACA group.

Results: Meta-analysis indicated no difference in surgery time (WMD = 0.01, 95% CI -0.35 to 0.36), total amount of blood loss (WMD = 0.14, 95% CI -0.09 to 0.37), transfusion rate (OR = 0.74, 95% CI 0.20 to 2.78), transfusion units per patient (SMD = -0.15, 95% CI -0.54 to 0.25), complications (OR = 0.75, 95% CI 0.37 to 1.55), and length of stay (SMD = -0.01, 95% CI -0.11 to 0.08).

Conclusions: Our results suggest that the effect of TXA is not superior to EACA in TKA. However, this conclusion still needs to be further confirmed by multicenter and large-sample clinical trials.

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Conflict of interest statement

The authors declare that they have no conflicts of interest.

Figures

Figure 1
Figure 1
The flowchart of literature retrieval.
Figure 2
Figure 2
The quality evaluation of the three RCTs.
Figure 3
Figure 3
Comparison of surgery time between tranexamic acid and epsilon-aminocaproic acid.
Figure 4
Figure 4
Comparison of total blood loss between tranexamic acid and epsilon-aminocaproic acid.
Figure 5
Figure 5
Comparison of transfusion rate between tranexamic acid and epsilon-aminocaproic acid.
Figure 6
Figure 6
Comparison of transfusion units per patient between tranexamic acid and epsilon-aminocaproic acid.
Figure 7
Figure 7
Comparison of complications between tranexamic acid and epsilon-aminocaproic acid.
Figure 8
Figure 8
Comparison of length of stay between tranexamic acid and epsilon-aminocaproic acid.
See this image and copyright information in PMC

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