Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Oct;10(3):181-189.
doi: 10.15420/aer.2021.32.

The Atrioventricular Conduction Axis and its Implications for Permanent Pacing

Affiliations
Review

The Atrioventricular Conduction Axis and its Implications for Permanent Pacing

José-Ángel Cabrera et al. Arrhythm Electrophysiol Rev. 2021 Oct.

Abstract

Extensive knowledge of the anatomy of the atrioventricular conduction axis, and its branches, is key to the success of permanent physiological pacing, either by capturing the His bundle, the left bundle branch or the adjacent septal regions. The inter-individual variability of the axis plays an important role in underscoring the technical difficulties known to exist in achieving a stable position of the stimulating leads. In this review, the key anatomical features of the location of the axis relative to the triangle of Koch, the aortic root, the inferior pyramidal space and the inferoseptal recess are summarised. In keeping with the increasing number of implants aimed at targeting the environs of the left bundle branch, an extensive review of the known variability in the pattern of ramification of the left bundle branch from the axis is included. This permits the authors to summarise in a pragmatic fashion the most relevant aspects to be taken into account when seeking to successfully deploy a permanent pacing lead.

Keywords: His bundle; His pacing; conduction axis pacing; inferior pyramidal space; inferoseptal recess; left bundle branch; penetrating atrioventricular bundle.

PubMed Disclaimer

Conflict of interest statement

Disclosure: RHA is on the Arrhythmia & Electrophysiology Review editorial board; this did not influence peer review. All other authors have no conflicts of interest to declare.

Figures

Figure 1:
Figure 1:. Human Atrioventricular Axis
Figure 2:
Figure 2:. Triangle of Koch, Inferoseptal Recess and Inferior Pyramidal Space
Figure 3:
Figure 3:. Inferior Pyramidal Space
Figure 4:
Figure 4:. Atrio and Interventricular Membranous Septum
Figure 5:
Figure 5:. Atrioventricular Node
Figure 6:
Figure 6:. Variable Location of the Atrioventricular Node and the Penetrating Bundle
Figure 7:
Figure 7:. Area of His and the Left Bundle Branch Pacing
Figure 8:
Figure 8:. Subaortic Outflow Tract and the Crest of the Muscular Septum
Figure 9:
Figure 9:. Left Bundle Branch
Figure 10:
Figure 10:. Angiographic Anatomy for Left Bundle Branch Pacing

References

    1. Huang W, Su L, Wu S et al. A novel pacing strategy with low and stable output: pacing the left bundle branch immediately beyond the conduction block. Can J Cardiol. 2017;33:1736–e1–3. doi: 10.1016/j.cjca.2017.09.013. - DOI - PubMed
    1. Liu P, Wang Q, Sun H et al. Left bundle branch pacing: Current knowledge and future prospects. Front Cardiovasc Med. 2021;8:630399. doi: 10.3389/fcvm.2021.630399. - DOI - PMC - PubMed
    1. Upadhyay GA, Vijayaraman P, Nayak HM et al. His corrective pacing or biventricular pacing for cardiac resynchronization in heart failure. J Am Coll Cardiol. 2019;74:157–9. doi: 10.1016/j.jacc.2019.04.026. - DOI - PubMed
    1. Zanon F, Ellenbogen KA, Dandamudi G et al. Permanent His-bundle pacing: a systematic literature review and meta-analysis. Europace. 2018;20:1819–26. doi: 10.1093/europace/euy058. - DOI - PubMed
    1. Zhang S, Zhou X, Gold MR. Left bundle branch pacing: JACC review topic of the week. J Am Coll Cardiol. 2019;74:3039–49. doi: 10.1016/j.jacc.2019.10.039. - DOI - PubMed

LinkOut - more resources