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Case Reports
. 2021 Oct 12:40:101893.
doi: 10.1016/j.eucr.2021.101893. eCollection 2022 Jan.

Diffuse large B-cell lymphoma presenting as LUTS: Clinical practice points

Soum D Lokeshwar  1 , Syed N Rahman  1 , Jamil Syed  1 , Thomas F Monaghan  2 , Benjamin Press  1 , Mark S Soloway  3
Affiliations
Case Reports

Diffuse large B-cell lymphoma presenting as LUTS: Clinical practice points

Soum D Lokeshwar et al. Urol Case Rep. .

Abstract

There is a paucity of management recommendations for patients with aggressive Diffuse large B cell lymphoma (DLBCL) of the bladder. A 57-year-old male patient presented with lower urinary tract symptoms underwent flexible cystoscopy and then bladder tumor biopsy. Through immediate staging CT scan, tumor and bone biopsies he was diagnosed with a 16 cm Stage IVa high-grade DLBCL. He was treated with DA EPOCH with only a partial response and was transitioned to R-ICE. For rarer presentations of bladder cancer during diagnostic cystoscopy there should be no delay in tumor imaging and involving medical oncology in early treatment decision making.

Keywords: Bladder cancer; Cystoscopy; Lymphoma.

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Conflict of interest statement

Syed N. Rahman has no direct or indirect commercial incentive associated with publishing this article and certifies that all conflicts of interest relevant to the subject matter discussed in the manuscript are the following: The additional authors have nothing to disclose.

Figures

Fig. 1
Fig. 1
CT Scan of Bladder Mass A. Coronal View CT Scan of Bladder Mass. The mass appears to be surrounding the bladder dome and lateral walls with evidence of hydronephrosis of the left ureter. There is upper tract dilatation with ureteral wall thickening B. Axial View CT scan: Tumor occupying much of the pelvic floor, largest diameter of mass 15.9 cm with bladder diameter measuring 11.1 cm due to compression.
Fig. 2
Fig. 2
Histology A. Biopsy of bladder mass from tumor resection B. . Tumor Cytology: Abundance of B cells.
See this image and copyright information in PMC

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