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. 1987 Oct;84(19):6854-8.
doi: 10.1073/pnas.84.19.6854.

Effective tumor immunotherapy directed against an oncogene-encoded product using a vaccinia virus vector

R Bernards  1 , A Destree, S McKenzie, E Gordon, R A Weinberg, D Panicali
Affiliations

Effective tumor immunotherapy directed against an oncogene-encoded product using a vaccinia virus vector

R Bernards et al. Proc Natl Acad Sci U S A. 1987 Oct.

Abstract

We have constructed a vaccinia virus recombinant that expresses the extracellular domain of the rat neu oncogene-encoded protein, a 185-kDa transmembrane glycoprotein termed p185. Strain NFS mice immunized with this recombinant virus developed a strong antibody response against the neu oncogene product and were fully protected against subsequent tumor challenge with neu-transformed NIH 3T3 cells. No tumor immunoprotection was found when recombinant virus-immunized mice were challenged with Ha-ras-transformed NIH 3T3 cells. These data indicate that immunization with a single oncogene-encoded antigen can fully and specifically protect animals against tumor cells bearing this antigen.

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