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. 2021 Dec;129(12):729-742.
doi: 10.1111/apm.13186.

High YAP and TEAD4 immunolabelings are associated with poor prognosis in patients with gallbladder cancer

Joo Young Kim  1 , You-Na Sung  2 , Seung-Mo Hong  2
Affiliations

High YAP and TEAD4 immunolabelings are associated with poor prognosis in patients with gallbladder cancer

Joo Young Kim et al. APMIS. 2021 Dec.

Abstract

Yes-associated protein (YAP) and TEA domain-containing sequence-specific transcription factors 4 (TEAD4) are essential components of the Hippo pathway. Abnormal regulation of the Hippo pathway contributes to the progression and metastasis of many cancer types. However, their clinicopathologic and prognostic significances have not been studied in gallbladder cancers. Here, we systematically evaluated the YAP and TEAD4 immunolabelings and their association with clinicopathologic characteristics and survival outcomes using 212 specimens of surgically resected gallbladder cancers. High YAP and TEAD4 immunolabelings were identified in 70 (33%) cases and were associated with infiltrative growth pattern, poor differentiation, perineural invasion, and advanced pT classification and AJCC stage. High YAP immunolabeling was significantly associated with high TEAD4 immunolabeling (p < 0.001). High immunolabeling levels of YAP or TEAD4 alone and the combined YAPhigh TEAD4high group were significantly associated with poor survival in both univariate (p < 0.001) and multivariate analyses (HR = 2.358; 95% CI, 1.369-4.061; p = 0.002). Therefore, the YAP and TEAD4 immunolabelings are associated with aggressive behavior of gallbladder cancers and may be useful as a prognostic indicator in patients with surgically resected gallbladder cancer.

Keywords: Gallbladder; Hippo; TEAD4; YAP; cancer; immunohistochemistry; prognosis.

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References

    1. Rawla P , Sunkara T , Thandra KC , Barsouk A . Epidemiology of gallbladder cancer. Clin Exp Hepatol. 2019;5:93-102.
    1. Ethun CG , Postlewait LM , Le N , Pawlik TM , Buettner S , Poultsides G , et al. A novel pathology-based preoperative risk score to predict locoregional residual and distant disease and survival for incidental gallbladder cancer: a 10-institution study from the U.S. extrahepatic biliary malignancy consortium. Ann Surg Oncol. 2017;24:1343-50.
    1. Hawkins WG , DeMatteo RP , Jarnagin WR , Ben-Porat L , Blumgart LH , Fong Y . Jaundice predicts advanced disease and early mortality in patients with gallbladder cancer. Ann Surg Oncol. 2004;11:310-5.
    1. Society AC. Cancer Facts and Figures 2017. Atlanta, GA: American Cancer Society; 2017.
    1. Zhou G-X , Li X-Y , Zhang QI , Zhao K , Zhang C-P , Xue C-H , et al. Effects of the hippo signaling pathway in human gastric cancer. Asian Pac J Cancer Prev. 2013;14:5199-205.

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