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Editorial
. 2021 Nov 16;10(22):e023673.
doi: 10.1161/JAHA.121.023673. Epub 2021 Nov 15.

Recruitment Practices in Multicenter Randomized Clinical Trials: Time for a Relook

Prakriti Gaba  1 , Deepak L Bhatt  1
Affiliations
Editorial

Recruitment Practices in Multicenter Randomized Clinical Trials: Time for a Relook

Prakriti Gaba et al. J Am Heart Assoc. .
No abstract available

Keywords: Editorials; mortality; prasugrel; randomized controlled trial; recruitment center; ticagrelor.

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Comment on

  • Ticagrelor or Prasugrel in Patients with Acute Coronary Syndromes.
    Schüpke S, Neumann FJ, Menichelli M, Mayer K, Bernlochner I, Wöhrle J, Richardt G, Liebetrau C, Witzenbichler B, Antoniucci D, Akin I, Bott-Flügel L, Fischer M, Landmesser U, Katus HA, Sibbing D, Seyfarth M, Janisch M, Boncompagni D, Hilz R, Rottbauer W, Okrojek R, Möllmann H, Hochholzer W, Migliorini A, Cassese S, Mollo P, Xhepa E, Kufner S, Strehle A, Leggewie S, Allali A, Ndrepepa G, Schühlen H, Angiolillo DJ, Hamm CW, Hapfelmeier A, Tölg R, Trenk D, Schunkert H, Laugwitz KL, Kastrati A; ISAR-REACT 5 Trial Investigators. Schüpke S, et al. N Engl J Med. 2019 Oct 17;381(16):1524-1534. doi: 10.1056/NEJMoa1908973. Epub 2019 Sep 1. N Engl J Med. 2019. PMID: 31475799 Clinical Trial.
  • Assessment of Impact of Patient Recruitment Volume on Risk Profile, Outcomes, and Treatment Effect in a Randomized Trial of Ticagrelor Versus Prasugrel in Acute Coronary Syndromes.
    Ndrepepa G, Neumann FJ, Menichelli M, Bernlochner I, Richardt G, Wöhrle J, Witzenbichler B, Mayer K, Cassese S, Gewalt S, Xhepa E, Kufner S, Sager HB, Joner M, Ibrahim T, Laugwitz KL, Schunkert H, Schüpke S, Kastrati A. Ndrepepa G, et al. J Am Heart Assoc. 2021 Nov 16;10(22):e021418. doi: 10.1161/JAHA.121.021418. Epub 2021 Nov 15. J Am Heart Assoc. 2021. PMID: 34779234 Free PMC article. Clinical Trial.

References

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    1. Vaduganathan M, Butler J, Krumholz HM, Itchhaporia D, Stecker EC, Bhatt DL. Regulation of cardiovascular therapies during the COVID‐19 public health emergency. J Am Coll Cardiol. 2020;76:2517–2521. doi: 10.1016/j.jacc.2020.09.594 - DOI - PMC - PubMed
    1. Gaba P, Bhatt DL. The COVID‐19 pandemic: a catalyst to improve clinical trials. Nat Rev Cardiol. 2020;17:673–675. doi: 10.1038/s41569-020-00439-7 - DOI - PMC - PubMed
    1. Goyal A, Schibler T, Alhanti B, Hannan KL, Granger CB, Blazing MA, Lopes RD, Alexander JH, Peterson ED, Rao SV, et al. Assessment of North American clinical research site performance during the start‐up of large cardiovascular clinical trials. JAMA Netw Open. 2021;4:e2117963. doi: 10.1001/jamanetworkopen.2021.17963 - DOI - PMC - PubMed
    1. Bhatt DL. Reconfiguring the cardiovascular clinical trial enterprise in the United States. JAMA Netw Open. 2021;4:e2118176. doi: 10.1001/jamanetworkopen.2021.18176 - DOI - PubMed

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