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. 2022 Sep;24(9):898-903.
doi: 10.1080/10286020.2021.1993833. Epub 2021 Nov 13.

Alkaloids from Phaeanthus vietnamensis with inhibitory effect on nitric oxide production lipopolysaccharide-stimulated in RAW264.7 macrophages

Duong Ngoc Tu  1 , Vu Thi Bich Hau  2 , Nguyen Thi Diep  1 , Ho Van Khanh  1 , Nguyen The Long  1 , Ha Thi Huyen Trang  3 , Nguyen Huy Hoang  4 , Phan Van Kiem  4 , Nguyen Xuan Nhiem  4
Affiliations

Alkaloids from Phaeanthus vietnamensis with inhibitory effect on nitric oxide production lipopolysaccharide-stimulated in RAW264.7 macrophages

Duong Ngoc Tu et al. J Asian Nat Prod Res. 2022 Sep.

Abstract

The chemical study of the acidic extract of Phaeanthus vietnamensis leaves led to the isolation of one new alkaloid, vietnamine A (1) and eight known alkaloids (R,S)-2N-norberbamunine (2), grisabine (3), 1S,1'R,O,O'-dimethylgrisabine (4), dauricine (5), neothalibrine (6), vietnamine (7), xylopine (8), and argentinine (9) by NMR and MS and comparing with the data reported in the literature. Compounds 1-9 were evaluated for inhibitory NO production in RAW 264.7 macrophages, LPS-stimulated. Compounds 1-3 significantly inhibited on NO production with the IC50 values of 6.8 ± 0.9, 9.8 ± 1.0, and 7.1 ± 0.4 µg/ml, respectively.

Keywords: Annonaceae; Phaeanthus vietnamensis; alkaloid; anti-inflammatory; vietnamine A.

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