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. 2022 Jun;26(6):1750-1792.
doi: 10.1007/s10461-021-03525-0. Epub 2021 Nov 15.

HIV Response Interventions that Integrate HIV Molecular Cluster and Social Network Analysis: A Systematic Review

Daniel J Gore  1 , Kellie Schueler  2 , Santhoshini Ramani  3 , Arno Uvin  3 , Gregory Phillips 2nd  4 , Moira McNulty  3   5 , Kayo Fujimoto  6 , John Schneider  7   8
Affiliations

HIV Response Interventions that Integrate HIV Molecular Cluster and Social Network Analysis: A Systematic Review

Daniel J Gore et al. AIDS Behav. 2022 Jun.

Abstract
in English, Spanish

Due to improved efficiency and reduced cost of viral sequencing, molecular cluster analysis can be feasibly utilized alongside existing human immunodeficiency virus (HIV) prevention strategies. The goal of this paper is to elucidate how HIV molecular cluster and social network analyses are being integrated to implement HIV response interventions. We searched PubMed, Scopus, PsycINFO, and Cochrane Library databases for studies incorporating both HIV molecular cluster and social network data. We identified 32 articles that combined analyses of HIV molecular sequences and social or sexual networks. All studies were descriptive. Six studies described network interventions informed by molecular and social data but did not fully evaluate their efficacy. There is no current standard for incorporating molecular and social network analyses to inform interventions or data demonstrating its utility. More research must be conducted to delineate benefits and best practices for leveraging molecular data for network-based interventions.

Debido a mejor eficiencia y costo reducido de la secuenciación viral, el análisis de complejos moleculares se puede utilizar de manera factible junto con las estrategias de prevención del virus de inmunodeficiencia humana (VIH) existentes. El objetivo de este repaso es de aclarar como integrar los análisis de las redes sociales y de los complejos moleculares del VIH para implementar intervenciones para controlar el VIH. Buscamos en las bases de datos de PubMed, Scopus, PsycINFO y Cochrane Library por estudios que incorporaran datos de redes sociales y grupos moleculares del VIH. Identificamos 32 estudios que combinaban análisis de secuencias moleculares del VIH y datos de redes sociales. Todos los estudios fueron descriptivos. Seis estudios describieron intervenciones informadas por datos moleculares y sociales, pero no evaluaron completamente su eficacia. No existe un estándar actual para incorporar análisis moleculares y sociales para informar intervenciones o datos que demuestren su eficacia. Se deben realizar más investigaciones para delinear los beneficios y las mejores prácticas de aplicar los datos moleculares y sociales para crear intervenciones del VIH.

Keywords: Cluster analysis; Cluster detection and response; Contact tracing; HIV; Social networks; Systematic review.

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Conflict of interest statement

Conflict of interest The authors have no conflicts of interest to declare that are relevant to the content of this article.

Figures

Fig. 1
Fig. 1
Preferred reporting items for systematic review and meta-analyses (PRISMA) flow diagram detailing systematic article screening and selection process
See this image and copyright information in PMC

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