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. 2021 Dec;40(4):645-659.
doi: 10.23876/j.krcp.20.271. Epub 2021 Oct 12.

Metabolic risks in living kidney donors in South Korea

Eunjeong Kang  1 , Jina Park  2 , Hyo Jeong Kim  3 , Sehoon Park  4 , Minsu Park  5 , Yaerim Kim  6 , Kwangsoo Kim  7 , Sang Min Park  8 , Dong-Wan Chae  9 , Ho Jun Chin  9 , Jung Pyo Lee  10 , Sik Lee  11 , Soo Wan Kim  12 , Jang-Hee Cho  13 , Miyeun Han  14 , Yong Chul Kim  15 , Yon Su Kim  15 , Insun Choi  3 , Hajeong Lee  15
Affiliations

Metabolic risks in living kidney donors in South Korea

Eunjeong Kang et al. Kidney Res Clin Pract. 2021 Dec.

Abstract

Background: Considering the growing prevalence of Western lifestyles and related chronic diseases occurring in South Korea, this study aimed to explore the progression of metabolic risk factors in living kidney donors.

Methods: This study enrolled living kidney donors from seven hospitals from 1982 to 2016. The controls were individuals that voluntarily received health check-ups from 1995 to 2016 that were matched with donors according to age, sex, diabetes status, baseline estimated glomerular filtration rate, and date of the medical record. Data on hyperuricemia, hypertension, hypercholesterolemia, and overweight/obesity were collected to determine metabolic risks. Logistic regressions with interaction terms between the medical record date and donor status were used to compare the trends in metabolic risks over time in the two groups.

Results: A total of 2,018 living kidney donors and matched non-donors were included. The median age was 44.0 years and 54.0% were women. The living kidney donors showed a lower absolute prevalence for all metabolic risk factors, except for those that were overweight/obese, than the non-donors. The proportion of subjects that were overweight/obese was consistently higher over time in the donor group. The changes over time in the prevalence of each metabolic risk were not significantly different between groups, except for a lower prevalence of metabolic risk factors ≥ 3 in donors.

Conclusion: Over time, metabolic risks in living kidney donors are generally the same as in non-donors, except for a lower prevalence of metabolic risk factors ≥3 in donors.

Keywords: Hypercholesterolemia; Hyperuricemia; Kidney transplantation; Living donors; Risk factors.

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Conflict of interest statement

Conflict of interest

All authors have no conflicts of interest to declare.

Figures

Figure 1.
Figure 1.. Study flow diagram.
SNUH, Seoul National University Hospital; SNUBH, Seoul National University Bundang Hospital; DM, diabetes mellitus; eGFR, estimated glomerular filtration rate; BMI, body mass index.
Figure 2.
Figure 2.. Epidemiologic trends of total living kidney donors from 1982 to 2018.
(A) Total number of living kidney transplants. (B) Age. (C) Sex. (D) Relationship between donors and recipients.
Figure 3.
Figure 3.. Proportional comparisons of each metabolic risk factor between living kidney donors and matched healthy non-donor controls from 1995 to 2016.
(A) Hypertension. (B) Hyperuricemia. (C) Hypercholesterolemia. (D) Overweight and obesity. (E) Donors with ≥3 metabolic risk factors.
See this image and copyright information in PMC

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