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. 2021 Nov 15;19(1):256.
doi: 10.1186/s12955-021-01889-4.

Comparing measurement properties of EQ-5D-Y-3L and EQ-5D-Y-5L in paediatric patients

Titi Sahidah Fitriana  1   2 , Fredrick Dermawan Purba  3 , Rina Rahmatika  4 , Riski Muhaimin  5 , Nur Melani Sari  6 , Gouke Bonsel  7   8 , Elly Stolk  7 , Jan J V Busschbach  9
Affiliations

Comparing measurement properties of EQ-5D-Y-3L and EQ-5D-Y-5L in paediatric patients

Titi Sahidah Fitriana et al. Health Qual Life Outcomes. .

Abstract

Background: The adult versions EQ-5D-3L and EQ-5D-5L have been extensive compared. This is not the case for the EQ-5D youth versions. The study aim was to compare the measurement properties and responsiveness of EQ-5D-Y-3L and EQ-5D-Y-5L in paediatric patients.

Methods: A sample of patients 8-16 years old with different diseases and a wide range of disease severity was asked to complete EQ-5D-Y-3L, EQ-5D-Y-5L, PedsQL Generic Core Scale, and selected, appropriate disease-specific instruments, three times. EQ-5D-Y-3L and EQ-5D-Y-5L were compared in terms of: feasibility, (re-)distribution properties, discriminatory power, convergent validity, test-retest reliability, and responsiveness.

Results: 286 participating patients suffered from one of the following diseases: major beta-thalassemia, haemophilia, acute lymphoblastic leukaemia, acute illness. Missing responses were comparable between versions of the EQ-5D-Y, suggesting comparable feasibility. The number of patients in the best health state (level profile 11111) was equal in both EQ-5D-Y versions. The projection of EQ-5D-Y-3L scores onto EQ-5D-Y-5L for all dimensions showed that the two additional levels in EQ-5D-Y-5L slightly improved the accuracy of patients in reporting their problems, especially if severe. Convergent validity with PedsQL and disease-specific measures showed that the two EQ-5D-Y versions performed about equally. Test-retest reliability (EQ-5D-Y-3L 0.78 vs EQ-5D-Y-5L 0.84), and sensitivity for detecting health changes, were both better in EQ-5D-Y-5L.

Conclusions: Extending the number of levels did not give clear superiority to EQ-5D-Y-5L over EQ-5D-Y-3L based on the criteria assessed in this study. However, increasing the number of levels benefitted EQ-5D-Y performance in the measurement of moderate to severe problems and especially in longitudinal study designs.

Keywords: EQ-5D-Y-3L paediatric patients; EQ-5D-Y-5L; Health-related quality of life; Psychometrics.

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Conflict of interest statement

TF, RR, RM, and NS report no conflicts of interest. FP, GB, ES, JB are either members of the EuroQol Group or are directly employed by the EuroQol Research Foundation.

Figures

Fig. 1
Fig. 1
Responsiveness of EQ-5D-Y-3L and EQ-5D-Y-5L
See this image and copyright information in PMC

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